Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Limonene and linalool hydroperoxides review : Pros and cons for routine patch testing

Ogueta, Isabel A. ; Brared Christensson, Johanna ; Giménez-Arnau, Elena ; Brans, Richard ; Wilkinson, Mark ; Stingeni, Luca ; Foti, Caterina ; Aerts, Olivier ; Svedman, Cecilia LU and Gonçalo, Margarida , et al. (2022) In Contact Dermatitis 87(1). p.1-12
Abstract

Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydroperoxide patch testing is warranted, examining the difficulties or challenges related to reading and interpreting hydroperoxide patch test results with currently available material, and assessing their relevance. Studies are increasingly pointing to high percentages of positive reactions in patients consecutively patch tested with these oxidized... (More)

Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydroperoxide patch testing is warranted, examining the difficulties or challenges related to reading and interpreting hydroperoxide patch test results with currently available material, and assessing their relevance. Studies are increasingly pointing to high percentages of positive reactions in patients consecutively patch tested with these oxidized products. An association between a positive clinical history and a strong patch test reaction has been described, but problems with doubtful/irritant reactions have also been reported. Considering the high frequency of relevant positive reactions, the incorporation of Lim-OOHs 0.3% and Lin-OOHs 1% in the baseline series may be justified. Since exposure, sensitization, and elicitation limits of Lim-OOHs and Lin-OOHs in the products still need to be better determined, an assessment of previous exposure, possible sensitizations, and reactions may help to improve the clinical assessment.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, hydroperoxides, limonene, linalool, patch test
in
Contact Dermatitis
volume
87
issue
1
pages
1 - 12
publisher
Wiley-Blackwell
external identifiers
  • pmid:35122274
  • scopus:85125035963
ISSN
0105-1873
DOI
10.1111/cod.14064
language
English
LU publication?
yes
id
f195d60c-0cbd-4e9d-8cfc-37b33de7a7a5
date added to LUP
2022-04-22 10:22:40
date last changed
2024-04-11 10:55:51
@article{f195d60c-0cbd-4e9d-8cfc-37b33de7a7a5,
  abstract     = {{<p>Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydroperoxide patch testing is warranted, examining the difficulties or challenges related to reading and interpreting hydroperoxide patch test results with currently available material, and assessing their relevance. Studies are increasingly pointing to high percentages of positive reactions in patients consecutively patch tested with these oxidized products. An association between a positive clinical history and a strong patch test reaction has been described, but problems with doubtful/irritant reactions have also been reported. Considering the high frequency of relevant positive reactions, the incorporation of Lim-OOHs 0.3% and Lin-OOHs 1% in the baseline series may be justified. Since exposure, sensitization, and elicitation limits of Lim-OOHs and Lin-OOHs in the products still need to be better determined, an assessment of previous exposure, possible sensitizations, and reactions may help to improve the clinical assessment.</p>}},
  author       = {{Ogueta, Isabel A. and Brared Christensson, Johanna and Giménez-Arnau, Elena and Brans, Richard and Wilkinson, Mark and Stingeni, Luca and Foti, Caterina and Aerts, Olivier and Svedman, Cecilia and Gonçalo, Margarida and Giménez-Arnau, Ana}},
  issn         = {{0105-1873}},
  keywords     = {{allergic contact dermatitis; hydroperoxides; limonene; linalool; patch test}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--12}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Limonene and linalool hydroperoxides review : Pros and cons for routine patch testing}},
  url          = {{http://dx.doi.org/10.1111/cod.14064}},
  doi          = {{10.1111/cod.14064}},
  volume       = {{87}},
  year         = {{2022}},
}