Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Five-Coordinate Platinum(II) Compounds Containing Sugar Ligands : Synthesis, Characterization, Cytotoxic Activity, and Interaction with Biological Macromolecules

Cucciolito, Maria Elena ; D'Amora, Angela ; De Feo, Gianmarco ; Ferraro, Giarita ; Giorgio, Anna ; Petruk, Ganna LU orcid ; Monti, Daria Maria ; Merlino, Antonello and Ruffo, Francesco (2018) In Inorganic Chemistry 57(6). p.3133-3143
Abstract

This article describes the synthesis and characterization of novel cationic five-coordinate Pt(II) complexes containing nitrogen sugar-based ligands. The cytotoxicity of the complexes was evaluated on different cell lines with the expectation that both the coordinative saturation and the sugar moiety cooperate to enhance their biological activity. In fact, the complexes resulted to be more active than cisplatin but still with little selectivity. They activate the apoptosis pathway. Binding of representative compounds with DNA was studied by ethidium bromide displacement assay and circular dichroism. Binding to model proteins was also investigated; the X-ray structure of the adduct formed in the reaction between a representative compound... (More)

This article describes the synthesis and characterization of novel cationic five-coordinate Pt(II) complexes containing nitrogen sugar-based ligands. The cytotoxicity of the complexes was evaluated on different cell lines with the expectation that both the coordinative saturation and the sugar moiety cooperate to enhance their biological activity. In fact, the complexes resulted to be more active than cisplatin but still with little selectivity. They activate the apoptosis pathway. Binding of representative compounds with DNA was studied by ethidium bromide displacement assay and circular dichroism. Binding to model proteins was also investigated; the X-ray structure of the adduct formed in the reaction between a representative compound and the model protein bovine pancreatic ribonuclease was obtained. The structure discloses an unprecedented interaction between a five-coordinate Pt(II) moiety and a His side chain.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Inorganic Chemistry
volume
57
issue
6
pages
3133 - 3143
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85044225445
  • pmid:29509011
ISSN
0020-1669
DOI
10.1021/acs.inorgchem.7b03118
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018 American Chemical Society.
id
f1ceea27-4940-40e8-90fa-d0ddf4ac416d
date added to LUP
2025-01-21 15:38:23
date last changed
2025-04-30 01:59:31
@article{f1ceea27-4940-40e8-90fa-d0ddf4ac416d,
  abstract     = {{<p>This article describes the synthesis and characterization of novel cationic five-coordinate Pt(II) complexes containing nitrogen sugar-based ligands. The cytotoxicity of the complexes was evaluated on different cell lines with the expectation that both the coordinative saturation and the sugar moiety cooperate to enhance their biological activity. In fact, the complexes resulted to be more active than cisplatin but still with little selectivity. They activate the apoptosis pathway. Binding of representative compounds with DNA was studied by ethidium bromide displacement assay and circular dichroism. Binding to model proteins was also investigated; the X-ray structure of the adduct formed in the reaction between a representative compound and the model protein bovine pancreatic ribonuclease was obtained. The structure discloses an unprecedented interaction between a five-coordinate Pt(II) moiety and a His side chain.</p>}},
  author       = {{Cucciolito, Maria Elena and D'Amora, Angela and De Feo, Gianmarco and Ferraro, Giarita and Giorgio, Anna and Petruk, Ganna and Monti, Daria Maria and Merlino, Antonello and Ruffo, Francesco}},
  issn         = {{0020-1669}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  pages        = {{3133--3143}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Inorganic Chemistry}},
  title        = {{Five-Coordinate Platinum(II) Compounds Containing Sugar Ligands : Synthesis, Characterization, Cytotoxic Activity, and Interaction with Biological Macromolecules}},
  url          = {{http://dx.doi.org/10.1021/acs.inorgchem.7b03118}},
  doi          = {{10.1021/acs.inorgchem.7b03118}},
  volume       = {{57}},
  year         = {{2018}},
}