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The multidimensional role of laminin γ2 (LAMC2) on cancer progression

Zhang, Xiaojuan LU ; Xie, Juan ; Fu, Tao ; Gao, Zhen ; Liu, Hengrui and Yang, Zhenshan LU orcid (2025) In Cancer Genetics 298-299. p.122-127
Abstract
Laminin, a critical component
of the basement membrane, plays an indispensable role in numerous
biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a
key player in the progression of cancer. This review delves into the
current understanding of LAMC2′s role, highlighting its significant
contribution to cancer development through promoting cell proliferation,
invasion, and vasculogenic mimicry, as well as inhibiting apoptosis.
Notably, LAMC2 expression is markedly increased in cancerous tissues
compared to normal counterparts, with higher levels of LAMC2 correlating
with poorer survival rates. This correlation underscores LAMC2′s
potential as a diagnostic and prognostic... (More)
Laminin, a critical component
of the basement membrane, plays an indispensable role in numerous
biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a
key player in the progression of cancer. This review delves into the
current understanding of LAMC2′s role, highlighting its significant
contribution to cancer development through promoting cell proliferation,
invasion, and vasculogenic mimicry, as well as inhibiting apoptosis.
Notably, LAMC2 expression is markedly increased in cancerous tissues
compared to normal counterparts, with higher levels of LAMC2 correlating
with poorer survival rates. This correlation underscores LAMC2′s
potential as a diagnostic and prognostic marker across various cancers.
Furthermore, the increasing importance of LAMC2 as a viable target for
cancer therapy is explored. This review aims to provide a thorough
overview of LAMC2′s involvement in cancer progression, prognostic
implications, potential therapeutic target, and involved signaling
pathway, and to outline future research directions in this promising
field. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, Laminin γ2, Prognostic, Therapeutic target
in
Cancer Genetics
volume
298-299
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:105016651023
  • pmid:40986946
ISSN
2210-7762
DOI
10.1016/j.cancergen.2025.09.007
language
English
LU publication?
yes
id
f1e26743-29d6-43be-8be5-58af7a6a7638
date added to LUP
2025-11-24 14:11:46
date last changed
2025-12-08 15:34:52
@article{f1e26743-29d6-43be-8be5-58af7a6a7638,
  abstract     = {{Laminin, a critical component <br>
of the basement membrane, plays an indispensable role in numerous <br>
biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a<br>
 key player in the progression of cancer. This review delves into the <br>
current understanding of LAMC2′s role, highlighting its significant <br>
contribution to cancer development through promoting cell proliferation,<br>
 invasion, and vasculogenic mimicry, as well as inhibiting apoptosis. <br>
Notably, LAMC2 expression is markedly increased in cancerous tissues <br>
compared to normal counterparts, with higher levels of LAMC2 correlating<br>
 with poorer survival rates. This correlation underscores LAMC2′s <br>
potential as a diagnostic and prognostic marker across various cancers. <br>
Furthermore, the increasing importance of LAMC2 as a viable target for <br>
cancer therapy is explored. This review aims to provide a thorough <br>
overview of LAMC2′s involvement in cancer progression, prognostic <br>
implications, potential therapeutic target, and involved signaling <br>
pathway, and to outline future research directions in this promising <br>
field.}},
  author       = {{Zhang, Xiaojuan and Xie, Juan and Fu, Tao and Gao, Zhen and Liu, Hengrui and Yang, Zhenshan}},
  issn         = {{2210-7762}},
  keywords     = {{Cancer; Laminin γ2; Prognostic; Therapeutic target}},
  language     = {{eng}},
  pages        = {{122--127}},
  publisher    = {{Elsevier}},
  series       = {{Cancer Genetics}},
  title        = {{The multidimensional role of laminin γ2 (LAMC2) on cancer progression}},
  url          = {{http://dx.doi.org/10.1016/j.cancergen.2025.09.007}},
  doi          = {{10.1016/j.cancergen.2025.09.007}},
  volume       = {{298-299}},
  year         = {{2025}},
}