Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases : An Overview
de Bem, Andreza Fabro ; Krolow, Rachel ; Farias, Hémelin Resende ; de Rezende, Victória Linden ; Gelain, Daniel Pens ; Moreira, José Cláudio Fonseca ; Duarte, João Miguel das Neves LU
and de Oliveira, Jade
(2021)
In Frontiers in Neuroscience
14.
- Abstract
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the... (More)
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.
(Less)
- author
- de Bem, Andreza Fabro
; Krolow, Rachel
; Farias, Hémelin Resende
; de Rezende, Victória Linden
; Gelain, Daniel Pens
; Moreira, José Cláudio Fonseca
; Duarte, João Miguel das Neves
LU
and de Oliveira, Jade
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer’s disease, diabetes, hypercholesterolemia, neurodegeneration, obesity, Parkinson’s disease, rodent models
- in
- Frontiers in Neuroscience
- volume
- 14
- article number
- 604150
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85100538833
- pmid:33536868
- ISSN
- 1662-4548
- DOI
- 10.3389/fnins.2020.604150
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: Funding. This research was supported by the Funda??o de Apoio ? Pesquisa do Distrito Federal (FAPDF grant 00193-00001324/2019-27), Funda??o de Apoio ? Pesquisa de Santa Catarina (FAPESC grant 16802017 06/2016), Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq grant 424809-2018-4), Brazilian National Institute of Science and Technology on Neuromodulation (485489/2014-1), and Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES). JD received research support from the Knut and Alice Wallenberg Foundation, the Tage Bl?cher Foundation, Dementiafonden, Swedish Foundation for International Cooperation in Research and Higher Education (BR2019-8508), Swedish Research Council (2019-01130), Swedish Diabetes Foundation (Dia2019-440), Crafoord Foundation (20200564), Direkt?r Albert P?hlssons Foundation, and the Lund University Diabetes Centre, which was funded by the Swedish Research Council (Strategic Research Area EXODIAB, grant 2009-1039) and the Swedish Foundation for Strategic Research (grant IRC15-0067). Publisher Copyright: © Copyright © 2021 de Bem, Krolow, Farias, de Rezende, Gelain, Moreira, Duarte and de Oliveira. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
- id
- f1fa5530-e3fa-4584-b3df-46136ceae51c
- date added to LUP
- 2021-02-24 08:51:41
- date last changed
- 2024-06-13 07:35:26
@article{f1fa5530-e3fa-4584-b3df-46136ceae51c,
abstract = {{<p>The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.</p>}},
author = {{de Bem, Andreza Fabro and Krolow, Rachel and Farias, Hémelin Resende and de Rezende, Victória Linden and Gelain, Daniel Pens and Moreira, José Cláudio Fonseca and Duarte, João Miguel das Neves and de Oliveira, Jade}},
issn = {{1662-4548}},
keywords = {{Alzheimer’s disease; diabetes; hypercholesterolemia; neurodegeneration; obesity; Parkinson’s disease; rodent models}},
language = {{eng}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Neuroscience}},
title = {{Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases : An Overview}},
url = {{http://dx.doi.org/10.3389/fnins.2020.604150}},
doi = {{10.3389/fnins.2020.604150}},
volume = {{14}},
year = {{2021}},
}