Advanced

Personal dialysis capacity (PDC(TM)) test : a multicentre clinical study

Van Biesen, Wim ; Carlsson, Ola ; Bergia, Roberto ; Brauner, Michael ; Christensson, Anders LU ; Genestier, Sandrine ; Haag-Weber, Marianne ; Heaf, James ; Joffe, Preben and Johansson, Ann-Cathrine , et al. (2003) In Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 18(4). p.96-788
Abstract

BACKGROUND: The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC(TM) program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute and water removal by simulation of different treatment regimens.

METHODS: This study evaluates the relevance of the PDC(TM) program when routinely used. The PDC(TM) data of 336 patients from nine different centres in Europe were evaluated.

RESULTS: The area parameter was 20 985+/-7578 cm/1.73 m(2) (mean+/-SD). The reabsorption of... (More)

BACKGROUND: The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC(TM) program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute and water removal by simulation of different treatment regimens.

METHODS: This study evaluates the relevance of the PDC(TM) program when routinely used. The PDC(TM) data of 336 patients from nine different centres in Europe were evaluated.

RESULTS: The area parameter was 20 985+/-7578 cm/1.73 m(2) (mean+/-SD). The reabsorption of fluid after dissipation of glucose, Jv(AR), was 1.97+/-1.00 ml/min/1.73 m(2). The large pore fluid flux, Jv(L), was 0.11+/-0.07 ml/min/1.73 m(2). A multivariate model for prediction of serum albumin included dialysate protein loss, Jv(L), Jv(AR), nPCR, A(0)/deltaX, BMI and gender (R(2)=0.81, P<0.001). Total clearance fell with increasing PD duration (P<0.001). A negative relation between A(0)/deltaX and ultrafiltration (rho=-0.26, P<0.05), a positive relation between A(0)/deltaX and peritoneal creatinine clearance (rho=0.52, P<0.05) and urea clearance (rho=0.36, P<0.05), and a positive relation between measured peritoneal creatinine and urea clearance (rho=0.64, P<0.01) was observed.

CONCLUSIONS: In summary, the present study shows that the PDC(TM) program is a robust, accurate method to describe the peritoneal membrane transport characteristics. Analysis of PDC(TM) data of large groups of patients, especially if followed up over time, can give interesting information on the physiology of the peritoneal membrane and the impact of different parameters on it.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Biological Transport, Blood Urea Nitrogen, Creatinine/blood, Cross-Sectional Studies, Dialysis Solutions/chemistry, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic/diagnosis, Kidney Function Tests, Linear Models, Male, Membranes, Artificial, Middle Aged, Multivariate Analysis, Patient Care Planning, Peritoneal Dialysis, Continuous Ambulatory/adverse effects, Peritoneum/metabolism, Permeability, Predictive Value of Tests, Probability, Risk Assessment, Treatment Outcome
in
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
volume
18
issue
4
pages
96 - 788
publisher
Oxford University Press
external identifiers
  • scopus:0037385328
  • pmid:12637650
ISSN
0931-0509
DOI
10.1093/ndt/gfg146
language
English
LU publication?
no
id
f2036180-014f-4ece-8900-aa1a6a49caad
date added to LUP
2019-05-16 13:56:35
date last changed
2020-01-13 01:48:20
@article{f2036180-014f-4ece-8900-aa1a6a49caad,
  abstract     = {<p>BACKGROUND: The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC(TM) program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute and water removal by simulation of different treatment regimens.</p><p>METHODS: This study evaluates the relevance of the PDC(TM) program when routinely used. The PDC(TM) data of 336 patients from nine different centres in Europe were evaluated.</p><p>RESULTS: The area parameter was 20 985+/-7578 cm/1.73 m(2) (mean+/-SD). The reabsorption of fluid after dissipation of glucose, Jv(AR), was 1.97+/-1.00 ml/min/1.73 m(2). The large pore fluid flux, Jv(L), was 0.11+/-0.07 ml/min/1.73 m(2). A multivariate model for prediction of serum albumin included dialysate protein loss, Jv(L), Jv(AR), nPCR, A(0)/deltaX, BMI and gender (R(2)=0.81, P&lt;0.001). Total clearance fell with increasing PD duration (P&lt;0.001). A negative relation between A(0)/deltaX and ultrafiltration (rho=-0.26, P&lt;0.05), a positive relation between A(0)/deltaX and peritoneal creatinine clearance (rho=0.52, P&lt;0.05) and urea clearance (rho=0.36, P&lt;0.05), and a positive relation between measured peritoneal creatinine and urea clearance (rho=0.64, P&lt;0.01) was observed.</p><p>CONCLUSIONS: In summary, the present study shows that the PDC(TM) program is a robust, accurate method to describe the peritoneal membrane transport characteristics. Analysis of PDC(TM) data of large groups of patients, especially if followed up over time, can give interesting information on the physiology of the peritoneal membrane and the impact of different parameters on it.</p>},
  author       = {Van Biesen, Wim and Carlsson, Ola and Bergia, Roberto and Brauner, Michael and Christensson, Anders and Genestier, Sandrine and Haag-Weber, Marianne and Heaf, James and Joffe, Preben and Johansson, Ann-Cathrine and Morel, Bertrand and Prischl, Friedrich and Verbeelen, Dirk and Vychytil, Andreas},
  issn         = {0931-0509},
  language     = {eng},
  number       = {4},
  pages        = {96--788},
  publisher    = {Oxford University Press},
  series       = {Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  title        = {Personal dialysis capacity (PDC(TM)) test : a multicentre clinical study},
  url          = {http://dx.doi.org/10.1093/ndt/gfg146},
  doi          = {10.1093/ndt/gfg146},
  volume       = {18},
  year         = {2003},
}