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CenTauR : Toward a universal scale and masks for standardizing tau imaging studies

Villemagne, Victor L. ; Leuzy, Antoine LU ; Bohorquez, Sandra Sanabria ; Bullich, Santiago ; Shimada, Hitoshi ; Rowe, Christopher C. ; Bourgeat, Pierrick ; Lopresti, Brian ; Huang, Kun and Krishnadas, Natasha , et al. (2023) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 15(3).
Abstract

INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A... (More)

INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauRz, was constructed. RESULTS: None of the regions known to display off-target signal were included in the masks. The CenTauRz allows robust discrimination between low and high levels of tau deposits. DISCUSSION: We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.

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type
Contribution to journal
publication status
published
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in
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
volume
15
issue
3
article number
e12454
publisher
Elsevier
external identifiers
  • pmid:37424964
  • scopus:85165556168
ISSN
2352-8729
DOI
10.1002/dad2.12454
language
English
LU publication?
yes
id
f23af2fb-26c2-4e8f-858d-dc18d7b45ee0
date added to LUP
2023-09-11 12:18:12
date last changed
2024-05-19 05:24:48
@article{f23af2fb-26c2-4e8f-858d-dc18d7b45ee0,
  abstract     = {{<p>INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either <sup>18</sup>F-flortaucipir, <sup>18</sup>F-MK6240, <sup>18</sup>F-PI2620, <sup>18</sup>F-PM-PBB3, <sup>18</sup>F-GTP1, or <sup>18</sup>F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR<sub>z</sub>, was constructed. RESULTS: None of the regions known to display off-target signal were included in the masks. The CenTauR<sub>z</sub> allows robust discrimination between low and high levels of tau deposits. DISCUSSION: We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.</p>}},
  author       = {{Villemagne, Victor L. and Leuzy, Antoine and Bohorquez, Sandra Sanabria and Bullich, Santiago and Shimada, Hitoshi and Rowe, Christopher C. and Bourgeat, Pierrick and Lopresti, Brian and Huang, Kun and Krishnadas, Natasha and Fripp, Jurgen and Takado, Yuhei and Gogola, Alexandra and Minhas, Davneet and Weimer, Robby and Higuchi, Makoto and Stephens, Andrew and Hansson, Oskar and Doré, Vincent}},
  issn         = {{2352-8729}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Elsevier}},
  series       = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}},
  title        = {{CenTauR : Toward a universal scale and masks for standardizing tau imaging studies}},
  url          = {{http://dx.doi.org/10.1002/dad2.12454}},
  doi          = {{10.1002/dad2.12454}},
  volume       = {{15}},
  year         = {{2023}},
}