CenTauR : Toward a universal scale and masks for standardizing tau imaging studies
(2023) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 15(3).- Abstract
INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A... (More)
INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauRz, was constructed. RESULTS: None of the regions known to display off-target signal were included in the masks. The CenTauRz allows robust discrimination between low and high levels of tau deposits. DISCUSSION: We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
- volume
- 15
- issue
- 3
- article number
- e12454
- publisher
- Elsevier
- external identifiers
-
- pmid:37424964
- scopus:85165556168
- ISSN
- 2352-8729
- DOI
- 10.1002/dad2.12454
- language
- English
- LU publication?
- yes
- id
- f23af2fb-26c2-4e8f-858d-dc18d7b45ee0
- date added to LUP
- 2023-09-11 12:18:12
- date last changed
- 2024-04-20 03:01:39
@article{f23af2fb-26c2-4e8f-858d-dc18d7b45ee0, abstract = {{<p>INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either <sup>18</sup>F-flortaucipir, <sup>18</sup>F-MK6240, <sup>18</sup>F-PI2620, <sup>18</sup>F-PM-PBB3, <sup>18</sup>F-GTP1, or <sup>18</sup>F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR<sub>z</sub>, was constructed. RESULTS: None of the regions known to display off-target signal were included in the masks. The CenTauR<sub>z</sub> allows robust discrimination between low and high levels of tau deposits. DISCUSSION: We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.</p>}}, author = {{Villemagne, Victor L. and Leuzy, Antoine and Bohorquez, Sandra Sanabria and Bullich, Santiago and Shimada, Hitoshi and Rowe, Christopher C. and Bourgeat, Pierrick and Lopresti, Brian and Huang, Kun and Krishnadas, Natasha and Fripp, Jurgen and Takado, Yuhei and Gogola, Alexandra and Minhas, Davneet and Weimer, Robby and Higuchi, Makoto and Stephens, Andrew and Hansson, Oskar and Doré, Vincent}}, issn = {{2352-8729}}, language = {{eng}}, number = {{3}}, publisher = {{Elsevier}}, series = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}}, title = {{CenTauR : Toward a universal scale and masks for standardizing tau imaging studies}}, url = {{http://dx.doi.org/10.1002/dad2.12454}}, doi = {{10.1002/dad2.12454}}, volume = {{15}}, year = {{2023}}, }