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The role of topical timolol in the treatment of infantile hemangiomas : A systematic review and meta-analysis

Khan, Maham; Boyce, Aaron; Prieto-Merino, David; Svensson, Åke LU ; Wedgeworth, Emma and Flohr, Carsten (2017) In Acta Dermato-Venereologica 97(10). p.1167-1171
Abstract

To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant... (More)

To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Beta-blocker, Infantile hemangioma, Timolol
in
Acta Dermato-Venereologica
volume
97
issue
10
pages
5 pages
publisher
Medical Journals Limited
external identifiers
  • scopus:85032669123
ISSN
0001-5555
DOI
10.2340/00015555-2681
language
English
LU publication?
yes
id
f23ee1b4-fa30-4fc8-bbab-f8bf72c6cab2
date added to LUP
2017-11-22 12:47:20
date last changed
2018-04-08 05:02:26
@article{f23ee1b4-fa30-4fc8-bbab-f8bf72c6cab2,
  abstract     = {<p>To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials.</p>},
  author       = {Khan, Maham and Boyce, Aaron and Prieto-Merino, David and Svensson, Åke and Wedgeworth, Emma and Flohr, Carsten},
  issn         = {0001-5555},
  keyword      = {Beta-blocker,Infantile hemangioma,Timolol},
  language     = {eng},
  month        = {11},
  number       = {10},
  pages        = {1167--1171},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {The role of topical timolol in the treatment of infantile hemangiomas : A systematic review and meta-analysis},
  url          = {http://dx.doi.org/10.2340/00015555-2681},
  volume       = {97},
  year         = {2017},
}