The fat-like gene of drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.
Castillejo-Lopez, Casimiro LU ; Martinez Arias, Wilma LU and Baumgartner, Stefan LU
(2004)
In Journal of Biological Chemistry
279(23).
p.24034-24043
- Abstract
- Fat cadherins constitute a subclass of the large cadherin family characterized by the presence of 34 cadherin motifs. To date, three mammalian Fat cadherins have been described; however, only limited information is known about the function of these molecules. In this paper, we describe the second fat cadherin in Drosophila, fat-like (ftl). We show that ftl is the true orthologue of vertebrate fat-like genes, whereas the previously characterized tumor suppressor cadherin, fat, is more distantly related as compared with ftl. Ftl is a large molecule of 4705 amino acids. It is expressed apically in luminal tissues such as trachea, salivary glands, proventriculus, and hindgut. Silencing of ftl results in the collapse of tracheal epithelia... (More)
- Fat cadherins constitute a subclass of the large cadherin family characterized by the presence of 34 cadherin motifs. To date, three mammalian Fat cadherins have been described; however, only limited information is known about the function of these molecules. In this paper, we describe the second fat cadherin in Drosophila, fat-like (ftl). We show that ftl is the true orthologue of vertebrate fat-like genes, whereas the previously characterized tumor suppressor cadherin, fat, is more distantly related as compared with ftl. Ftl is a large molecule of 4705 amino acids. It is expressed apically in luminal tissues such as trachea, salivary glands, proventriculus, and hindgut. Silencing of ftl results in the collapse of tracheal epithelia giving rise to breaks, deletions, and sac-like structures. Other tubular organs such as proventriculus, salivary glands, and hindgut are also malformed or missing. These data suggest that Ftl is required for morphogenesis and maintenance of tubular structures of ectodermal origin and underline its similarity in function to a reported lethal mouse knock-out of fat1 where glomerular epithelial processes collapse. Based on our results, we propose a model where Ftl acts as a spacer to keep tubular epithelia apart rather than the previously described adhesive properties of the cadherin superfamily. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/120959
- author
- Castillejo-Lopez, Casimiro
LU
; Martinez Arias, Wilma
LU
and Baumgartner, Stefan
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biological Chemistry
- volume
- 279
- issue
- 23
- pages
- 24034 - 24043
- publisher
- American Society for Biochemistry and Molecular Biology
- external identifiers
-
- wos:000221702500025
- scopus:2642555545
- ISSN
- 1083-351X
- DOI
- 10.1074/jbc.M313878200
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Developmental biology (LUR000007), Invertebral Developmental Biology, Udo Haecker's group (013212048), Invertebral Developmental Biology, Stefan Baumgartner's group (013212047)
- id
- f2a64334-0d86-4eee-b88f-02587b0da75e (old id 120959)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15047711&dopt=Abstract
- date added to LUP
- 2016-04-01 11:53:27
- date last changed
- 2022-04-13 02:52:12
@article{f2a64334-0d86-4eee-b88f-02587b0da75e,
abstract = {{Fat cadherins constitute a subclass of the large cadherin family characterized by the presence of 34 cadherin motifs. To date, three mammalian Fat cadherins have been described; however, only limited information is known about the function of these molecules. In this paper, we describe the second fat cadherin in Drosophila, fat-like (ftl). We show that ftl is the true orthologue of vertebrate fat-like genes, whereas the previously characterized tumor suppressor cadherin, fat, is more distantly related as compared with ftl. Ftl is a large molecule of 4705 amino acids. It is expressed apically in luminal tissues such as trachea, salivary glands, proventriculus, and hindgut. Silencing of ftl results in the collapse of tracheal epithelia giving rise to breaks, deletions, and sac-like structures. Other tubular organs such as proventriculus, salivary glands, and hindgut are also malformed or missing. These data suggest that Ftl is required for morphogenesis and maintenance of tubular structures of ectodermal origin and underline its similarity in function to a reported lethal mouse knock-out of fat1 where glomerular epithelial processes collapse. Based on our results, we propose a model where Ftl acts as a spacer to keep tubular epithelia apart rather than the previously described adhesive properties of the cadherin superfamily.}},
author = {{Castillejo-Lopez, Casimiro and Martinez Arias, Wilma and Baumgartner, Stefan}},
issn = {{1083-351X}},
language = {{eng}},
number = {{23}},
pages = {{24034--24043}},
publisher = {{American Society for Biochemistry and Molecular Biology}},
series = {{Journal of Biological Chemistry}},
title = {{The fat-like gene of drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.}},
url = {{http://dx.doi.org/10.1074/jbc.M313878200}},
doi = {{10.1074/jbc.M313878200}},
volume = {{279}},
year = {{2004}},
}