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An analysis of gender differences in treatment and outcome of periampullary tumours in Sweden – A national cohort study

Williamsson, Caroline LU ; Rystedt, Jenny LU and Andersson, Bodil LU orcid (2021) In HPB 23(6). p.847-853
Abstract

Background: Little is known of possible gender differences in treatment of periampullary tumours and outcome after pancreatoduodenectomy (PD), and the aim of this study was therefore to investigate any variances from national multicentre perspective. Methods: Data from the Swedish National Registry for Pancreatic and Periampullary Cancer for all patients diagnosed with a periampullary tumour from 2012 throughout 2017 was collected. The material was analysed in two groups, men and women, for palliative treatment and curative intended resection. Results: A total of 5677 patients were included, 2906 (51%) men and 2771 (49%) women. Women were older than men, 72 (65–78) years vs. 70 (64–76), p < 0.001. A lesser proportion of women were... (More)

Background: Little is known of possible gender differences in treatment of periampullary tumours and outcome after pancreatoduodenectomy (PD), and the aim of this study was therefore to investigate any variances from national multicentre perspective. Methods: Data from the Swedish National Registry for Pancreatic and Periampullary Cancer for all patients diagnosed with a periampullary tumour from 2012 throughout 2017 was collected. The material was analysed in two groups, men and women, for palliative treatment and curative intended resection. Results: A total of 5677 patients were included, 2906 (51%) men and 2771 (49%) women. Women were older than men, 72 (65–78) years vs. 70 (64–76), p < 0.001. A lesser proportion of women were planned for resection (1131 (41%) vs. 1288 (44%), p = 0.008), but after adjusting for age and tumour location no difference was seen. Postoperative morbidity was equal, but women had significantly better long-term survival than men. The survival was equal for palliative men and women. Conclusion: No gender bias could be established when analysing treatment for periampullary tumours in Sweden, even though less women were offered surgery. Data suggest that even though women were older they tolerate surgery well and hence offering PD at a higher age for women could be suggested.

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publication status
published
subject
in
HPB
volume
23
issue
6
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:85097746077
  • pmid:33339715
ISSN
1365-182X
DOI
10.1016/j.hpb.2020.11.1145
language
English
LU publication?
yes
id
f2b31aee-0d5b-4a7c-9080-335e38e51831
date added to LUP
2021-01-11 07:26:36
date last changed
2025-01-24 03:31:49
@article{f2b31aee-0d5b-4a7c-9080-335e38e51831,
  abstract     = {{<p>Background: Little is known of possible gender differences in treatment of periampullary tumours and outcome after pancreatoduodenectomy (PD), and the aim of this study was therefore to investigate any variances from national multicentre perspective. Methods: Data from the Swedish National Registry for Pancreatic and Periampullary Cancer for all patients diagnosed with a periampullary tumour from 2012 throughout 2017 was collected. The material was analysed in two groups, men and women, for palliative treatment and curative intended resection. Results: A total of 5677 patients were included, 2906 (51%) men and 2771 (49%) women. Women were older than men, 72 (65–78) years vs. 70 (64–76), p &lt; 0.001. A lesser proportion of women were planned for resection (1131 (41%) vs. 1288 (44%), p = 0.008), but after adjusting for age and tumour location no difference was seen. Postoperative morbidity was equal, but women had significantly better long-term survival than men. The survival was equal for palliative men and women. Conclusion: No gender bias could be established when analysing treatment for periampullary tumours in Sweden, even though less women were offered surgery. Data suggest that even though women were older they tolerate surgery well and hence offering PD at a higher age for women could be suggested.</p>}},
  author       = {{Williamsson, Caroline and Rystedt, Jenny and Andersson, Bodil}},
  issn         = {{1365-182X}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{847--853}},
  publisher    = {{Elsevier}},
  series       = {{HPB}},
  title        = {{An analysis of gender differences in treatment and outcome of periampullary tumours in Sweden – A national cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.hpb.2020.11.1145}},
  doi          = {{10.1016/j.hpb.2020.11.1145}},
  volume       = {{23}},
  year         = {{2021}},
}