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Decreased spermatogonial numbers in boys with severe haematological diseases

Lahtinen, Atte K. ; Funke, Miriam ; Krallmann, Claudia ; Wyrwoll, Margot J. ; Jarisch, Andrea ; Yang, Yifan ; Bjarnason, Ragnar ; Romerius, Patrik LU ; Sundin, Mikael and Norén-Nyström, Ulrika , et al. (2024) In British Journal of Haematology 205(1). p.229-235
Abstract

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe... (More)

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone marrow failure, fertility, immunodeficiency, MDS, myeloproliferative disease, stem cell transplantation
in
British Journal of Haematology
volume
205
issue
1
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:38810989
  • scopus:85194578908
ISSN
0007-1048
DOI
10.1111/bjh.19572
language
English
LU publication?
yes
id
f3152737-420d-45c9-931c-4f89887d28cd
date added to LUP
2024-10-09 15:34:51
date last changed
2024-10-10 03:00:08
@article{f3152737-420d-45c9-931c-4f89887d28cd,
  abstract     = {{<p>This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.</p>}},
  author       = {{Lahtinen, Atte K. and Funke, Miriam and Krallmann, Claudia and Wyrwoll, Margot J. and Jarisch, Andrea and Yang, Yifan and Bjarnason, Ragnar and Romerius, Patrik and Sundin, Mikael and Norén-Nyström, Ulrika and Langenskiöld, Cecilia and Cremers, Jann Frederik and Kliesch, Sabine and Stukenborg, Jan Bernd and Neuhaus, Nina and Jahnukainen, Kirsi}},
  issn         = {{0007-1048}},
  keywords     = {{bone marrow failure; fertility; immunodeficiency; MDS; myeloproliferative disease; stem cell transplantation}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{229--235}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{Decreased spermatogonial numbers in boys with severe haematological diseases}},
  url          = {{http://dx.doi.org/10.1111/bjh.19572}},
  doi          = {{10.1111/bjh.19572}},
  volume       = {{205}},
  year         = {{2024}},
}