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The dentate gyrus in hypoglycemia : Pathology implicating excititoxin-mediated neuronal necrosis

Auer, R.; Kalimo, H.; Olsson, Y. and Wieloch, T. LU (1985) In Acta Neuropathologica 67(3-4). p.279-288
Abstract

A detailed light- and electron-microscopic study of the damage to the rat dentate gyrus in hypoglycemia was undertaken, in view of the previously advanced hypothesis that hypoglycemic nerve cell injury is mediated by a released neurotoxin. The distribution of neuronal necrosis showed a relationship to the subarachnoid cisterns. Electron microscopy of the dentate granule cells and their apical dendrites revealed dendrosomal, axon-sparing neuronal pathology. Dentate granule cells were affected first in the dendrites in the outer layer of the stratum moleculare, sparing axons of passage and terminal boutons. Subsequently, the neuronal perikarya were affected, and Wallerian degeneration of axons followed. Cell membrane abnormalities... (More)

A detailed light- and electron-microscopic study of the damage to the rat dentate gyrus in hypoglycemia was undertaken, in view of the previously advanced hypothesis that hypoglycemic nerve cell injury is mediated by a released neurotoxin. The distribution of neuronal necrosis showed a relationship to the subarachnoid cisterns. Electron microscopy of the dentate granule cells and their apical dendrites revealed dendrosomal, axon-sparing neuronal pathology. Dentate granule cells were affected first in the dendrites in the outer layer of the stratum moleculare, sparing axons of passage and terminal boutons. Subsequently, the neuronal perikarya were affected, and Wallerian degeneration of axons followed. Cell membrane abnormalities preceded the appearance of mitochondrial flocculent densities and degradation of the cytoskeleton, and are suggested to be early lethal changes. The observed early dendrotoxic changes, and the dendrosomal, axon-sparing nature of the lesion implicate an excitotoxin-mediated neuronal necrosis in hypoglycemia.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Cerebrospinal fluid (CSF), Dendrites, Dentate, Excitotoxin, Hypoglycemia, Membrane breaks, Neuronal necrosis
in
Acta Neuropathologica
volume
67
issue
3-4
pages
10 pages
publisher
Springer
external identifiers
  • scopus:0021878540
ISSN
0001-6322
DOI
10.1007/BF00687813
language
English
LU publication?
yes
id
f3290977-6926-4705-8556-6e172002ec79
date added to LUP
2019-06-13 17:22:13
date last changed
2019-09-12 21:09:03
@article{f3290977-6926-4705-8556-6e172002ec79,
  abstract     = {<p>A detailed light- and electron-microscopic study of the damage to the rat dentate gyrus in hypoglycemia was undertaken, in view of the previously advanced hypothesis that hypoglycemic nerve cell injury is mediated by a released neurotoxin. The distribution of neuronal necrosis showed a relationship to the subarachnoid cisterns. Electron microscopy of the dentate granule cells and their apical dendrites revealed dendrosomal, axon-sparing neuronal pathology. Dentate granule cells were affected first in the dendrites in the outer layer of the stratum moleculare, sparing axons of passage and terminal boutons. Subsequently, the neuronal perikarya were affected, and Wallerian degeneration of axons followed. Cell membrane abnormalities preceded the appearance of mitochondrial flocculent densities and degradation of the cytoskeleton, and are suggested to be early lethal changes. The observed early dendrotoxic changes, and the dendrosomal, axon-sparing nature of the lesion implicate an excitotoxin-mediated neuronal necrosis in hypoglycemia.</p>},
  author       = {Auer, R. and Kalimo, H. and Olsson, Y. and Wieloch, T.},
  issn         = {0001-6322},
  keyword      = {Cerebrospinal fluid (CSF),Dendrites,Dentate,Excitotoxin,Hypoglycemia,Membrane breaks,Neuronal necrosis},
  language     = {eng},
  month        = {09},
  number       = {3-4},
  pages        = {279--288},
  publisher    = {Springer},
  series       = {Acta Neuropathologica},
  title        = {The dentate gyrus in hypoglycemia : Pathology implicating excititoxin-mediated neuronal necrosis},
  url          = {http://dx.doi.org/10.1007/BF00687813},
  volume       = {67},
  year         = {1985},
}