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Increase of bikunin and alpha1-microglobulin concentrations in urine of rats during pregnancy is due to decreased tubular reabsorption

Blom, Anna M ; Falkenberg, Cecilia LU ; Sjöquist, Mats ; Eriksson, Ulf J ; Åkerström, Bo LU and Fries, Erika (1997) In Biochimica et biophysica acta 1361(2). p.198-202
Abstract

Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine increased 3-fold towards the end of the pregnancy, whereas those of albumin and orosomucoid did not. There were no significant changes in either the bikunin/alpha1-microglobulin mRNA level or the concentrations of the two proteins in serum. These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are... (More)

Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine increased 3-fold towards the end of the pregnancy, whereas those of albumin and orosomucoid did not. There were no significant changes in either the bikunin/alpha1-microglobulin mRNA level or the concentrations of the two proteins in serum. These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are normal during pregnancy but that the tubular reabsorption of these proteins is decreased.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Alpha-Globulins/analysis, Animals, Female, Glycoproteins/blood, Kidney Tubules/metabolism, Liver/metabolism, Membrane Glycoproteins, Orosomucoid/analysis, Pregnancy/blood, RNA, Messenger/isolation & purification, Rats, Rats, Sprague-Dawley, Trypsin Inhibitor, Kunitz Soybean
in
Biochimica et biophysica acta
volume
1361
issue
2
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:9300801
ISSN
0006-3002
DOI
10.1016/S0925-4439(97)00040-9
language
English
LU publication?
yes
id
f329a62c-3e37-4814-9d5e-a246539ad74b
date added to LUP
2019-05-22 10:16:25
date last changed
2019-11-21 04:01:03
@article{f329a62c-3e37-4814-9d5e-a246539ad74b,
  abstract     = {<p>Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine increased 3-fold towards the end of the pregnancy, whereas those of albumin and orosomucoid did not. There were no significant changes in either the bikunin/alpha1-microglobulin mRNA level or the concentrations of the two proteins in serum. These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are normal during pregnancy but that the tubular reabsorption of these proteins is decreased.</p>},
  author       = {Blom, Anna M and Falkenberg, Cecilia and Sjöquist, Mats and Eriksson, Ulf J and Åkerström, Bo and Fries, Erika},
  issn         = {0006-3002},
  language     = {eng},
  month        = {08},
  number       = {2},
  pages        = {198--202},
  publisher    = {Elsevier},
  series       = {Biochimica et biophysica acta},
  title        = {Increase of bikunin and alpha1-microglobulin concentrations in urine of rats during pregnancy is due to decreased tubular reabsorption},
  url          = {http://dx.doi.org/10.1016/S0925-4439(97)00040-9},
  doi          = {10.1016/S0925-4439(97)00040-9},
  volume       = {1361},
  year         = {1997},
}