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Smoking is a strong risk factor for rheumatoid nodules in early rheumatoid arthritis

Nyhall-Wahlin, BM ; Jacobsson, Lennart LU ; Petersson, IF and Turesson, Carl LU (2006) In Annals of the Rheumatic Diseases 65(5). p.601-606
Abstract
Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identified. Nodular patients were each compared with two age and sex matched controls without nodules from the same cohort. A detailed self administered tobacco use questionnaire was answered by 210 patients (63%). Results: Seventy patients were current smokers, 71 former smokers, and 69 had never smoked. Current smoking and former smoking were more... (More)
Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identified. Nodular patients were each compared with two age and sex matched controls without nodules from the same cohort. A detailed self administered tobacco use questionnaire was answered by 210 patients (63%). Results: Seventy patients were current smokers, 71 former smokers, and 69 had never smoked. Current smoking and former smoking were more common in patients with rheumatoid nodules compared with controls (86% v 59%) in both sexes. Positive rheumatoid factor (RF) was found more often among cases with nodules than controls (78% v 64%). Using detailed information from the questionnaires with conditional logistic regression analyses, ever having smoked was associated with an increased risk of the presence of rheumatoid nodules ( odds ratio ( OR) = 7.3 (95% confidence interval, 2.3 to 23.6); p = 0.001). The risk of having nodules was not obviously dose dependent when smoking duration as well as smoking amount were examined. A stratified analysis showed that only RF positive smokers had an increased risk of rheumatoid nodules. Smoking was associated with rheumatoid nodules among both men ( p = 0.006) and women ( p = 0.001). Tobacco use other than smoking ( n = 31) was not associated with an increased risk of nodules ( OR = 0.8 (0.2 to 3.4); p = 0.813). Conclusions: There is a strong association between smoking and rheumatoid nodules in early seropositive rheumatoid arthritis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
65
issue
5
pages
601 - 606
publisher
British Medical Association
external identifiers
  • wos:000236764900008
  • pmid:16166104
  • scopus:33646265526
  • pmid:16166104
ISSN
1468-2060
DOI
10.1136/ard.2005.039172
language
English
LU publication?
yes
id
f334180f-8f4b-4a98-8799-70cd34902d97 (old id 693379)
date added to LUP
2016-04-01 16:37:16
date last changed
2019-12-04 05:23:10
@article{f334180f-8f4b-4a98-8799-70cd34902d97,
  abstract     = {Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identified. Nodular patients were each compared with two age and sex matched controls without nodules from the same cohort. A detailed self administered tobacco use questionnaire was answered by 210 patients (63%). Results: Seventy patients were current smokers, 71 former smokers, and 69 had never smoked. Current smoking and former smoking were more common in patients with rheumatoid nodules compared with controls (86% v 59%) in both sexes. Positive rheumatoid factor (RF) was found more often among cases with nodules than controls (78% v 64%). Using detailed information from the questionnaires with conditional logistic regression analyses, ever having smoked was associated with an increased risk of the presence of rheumatoid nodules ( odds ratio ( OR) = 7.3 (95% confidence interval, 2.3 to 23.6); p = 0.001). The risk of having nodules was not obviously dose dependent when smoking duration as well as smoking amount were examined. A stratified analysis showed that only RF positive smokers had an increased risk of rheumatoid nodules. Smoking was associated with rheumatoid nodules among both men ( p = 0.006) and women ( p = 0.001). Tobacco use other than smoking ( n = 31) was not associated with an increased risk of nodules ( OR = 0.8 (0.2 to 3.4); p = 0.813). Conclusions: There is a strong association between smoking and rheumatoid nodules in early seropositive rheumatoid arthritis.},
  author       = {Nyhall-Wahlin, BM and Jacobsson, Lennart and Petersson, IF and Turesson, Carl},
  issn         = {1468-2060},
  language     = {eng},
  number       = {5},
  pages        = {601--606},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Smoking is a strong risk factor for rheumatoid nodules in early rheumatoid arthritis},
  url          = {http://dx.doi.org/10.1136/ard.2005.039172},
  doi          = {10.1136/ard.2005.039172},
  volume       = {65},
  year         = {2006},
}