Evidence of support used for drug treatments in pediatric cardiology
(2021) In Health Science Reports 4(2).- Abstract
Background and aims: Clinical support systems are widely used in pediatric care. The aim of this study was to assess the support for drug treatments used at pediatric cardiac wards and intensive care units in Sweden. Methods: Drug information, such as type of drug, indication, dose, and route of administration, for all in-hospital pediatric cardiac patients, was included in the study. Treatments were classified as either on-label (based on product information) or off-label. Support for off-label treatment was stratified by the use of clinical support systems (the national database on drugs, local, or other clinical experience guidelines). Results: In all, 28 patients were included in the study. The total number of drug treatments was... (More)
Background and aims: Clinical support systems are widely used in pediatric care. The aim of this study was to assess the support for drug treatments used at pediatric cardiac wards and intensive care units in Sweden. Methods: Drug information, such as type of drug, indication, dose, and route of administration, for all in-hospital pediatric cardiac patients, was included in the study. Treatments were classified as either on-label (based on product information) or off-label. Support for off-label treatment was stratified by the use of clinical support systems (the national database on drugs, local, or other clinical experience guidelines). Results: In all, 28 patients were included in the study. The total number of drug treatments was 233, encompassing 65 different drugs. Overall, 175 (75%) treatments were off-label. A majority of off-label drug treatments were supported by other sources of information shared by experts. A total of 7% of the drug treatments were used without support. Conclusion: Off-label drug treatment is still common in Swedish pediatric cardiac care. However, the majority of treatments were supported by the experience shared in clinical support systems. Key Points: Seventy-five percent of all prescriptions in pediatric cardiology care were off-label. A majority of patients received three or more drug treatments off-label. Use of clinical support systems and guidelines was common, but in 7% of all drug treatments, no support was found for the chosen treatment.
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- author
- Back, Julia ; Wåhlander, Håkan ; Hanseus, Katarina LU ; Bergman, Gunnar and Naumburg, Estelle
- organization
- publishing date
- 2021-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- drugs, medical support systems, off-label, pediatric cardiology, pediatrics
- in
- Health Science Reports
- volume
- 4
- issue
- 2
- article number
- e288
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:34013068
- scopus:85118905294
- ISSN
- 2398-8835
- DOI
- 10.1002/hsr2.288
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC.
- id
- f33feae4-6827-42a1-abff-a8b22188d90b
- date added to LUP
- 2021-12-03 15:26:36
- date last changed
- 2024-06-15 22:08:34
@article{f33feae4-6827-42a1-abff-a8b22188d90b,
abstract = {{<p>Background and aims: Clinical support systems are widely used in pediatric care. The aim of this study was to assess the support for drug treatments used at pediatric cardiac wards and intensive care units in Sweden. Methods: Drug information, such as type of drug, indication, dose, and route of administration, for all in-hospital pediatric cardiac patients, was included in the study. Treatments were classified as either on-label (based on product information) or off-label. Support for off-label treatment was stratified by the use of clinical support systems (the national database on drugs, local, or other clinical experience guidelines). Results: In all, 28 patients were included in the study. The total number of drug treatments was 233, encompassing 65 different drugs. Overall, 175 (75%) treatments were off-label. A majority of off-label drug treatments were supported by other sources of information shared by experts. A total of 7% of the drug treatments were used without support. Conclusion: Off-label drug treatment is still common in Swedish pediatric cardiac care. However, the majority of treatments were supported by the experience shared in clinical support systems. Key Points: Seventy-five percent of all prescriptions in pediatric cardiology care were off-label. A majority of patients received three or more drug treatments off-label. Use of clinical support systems and guidelines was common, but in 7% of all drug treatments, no support was found for the chosen treatment.</p>}},
author = {{Back, Julia and Wåhlander, Håkan and Hanseus, Katarina and Bergman, Gunnar and Naumburg, Estelle}},
issn = {{2398-8835}},
keywords = {{drugs; medical support systems; off-label; pediatric cardiology; pediatrics}},
language = {{eng}},
number = {{2}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Health Science Reports}},
title = {{Evidence of support used for drug treatments in pediatric cardiology}},
url = {{http://dx.doi.org/10.1002/hsr2.288}},
doi = {{10.1002/hsr2.288}},
volume = {{4}},
year = {{2021}},
}