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Evidence of support used for drug treatments in pediatric cardiology

Back, Julia ; Wåhlander, Håkan ; Hanseus, Katarina LU ; Bergman, Gunnar and Naumburg, Estelle (2021) In Health Science Reports 4(2).
Abstract

Background and aims: Clinical support systems are widely used in pediatric care. The aim of this study was to assess the support for drug treatments used at pediatric cardiac wards and intensive care units in Sweden. Methods: Drug information, such as type of drug, indication, dose, and route of administration, for all in-hospital pediatric cardiac patients, was included in the study. Treatments were classified as either on-label (based on product information) or off-label. Support for off-label treatment was stratified by the use of clinical support systems (the national database on drugs, local, or other clinical experience guidelines). Results: In all, 28 patients were included in the study. The total number of drug treatments was... (More)

Background and aims: Clinical support systems are widely used in pediatric care. The aim of this study was to assess the support for drug treatments used at pediatric cardiac wards and intensive care units in Sweden. Methods: Drug information, such as type of drug, indication, dose, and route of administration, for all in-hospital pediatric cardiac patients, was included in the study. Treatments were classified as either on-label (based on product information) or off-label. Support for off-label treatment was stratified by the use of clinical support systems (the national database on drugs, local, or other clinical experience guidelines). Results: In all, 28 patients were included in the study. The total number of drug treatments was 233, encompassing 65 different drugs. Overall, 175 (75%) treatments were off-label. A majority of off-label drug treatments were supported by other sources of information shared by experts. A total of 7% of the drug treatments were used without support. Conclusion: Off-label drug treatment is still common in Swedish pediatric cardiac care. However, the majority of treatments were supported by the experience shared in clinical support systems. Key Points: Seventy-five percent of all prescriptions in pediatric cardiology care were off-label. A majority of patients received three or more drug treatments off-label. Use of clinical support systems and guidelines was common, but in 7% of all drug treatments, no support was found for the chosen treatment.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
drugs, medical support systems, off-label, pediatric cardiology, pediatrics
in
Health Science Reports
volume
4
issue
2
article number
e288
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85118905294
  • pmid:34013068
ISSN
2398-8835
DOI
10.1002/hsr2.288
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC.
id
f33feae4-6827-42a1-abff-a8b22188d90b
date added to LUP
2021-12-03 15:26:36
date last changed
2022-08-04 20:58:15
@article{f33feae4-6827-42a1-abff-a8b22188d90b,
  abstract     = {{<p>Background and aims: Clinical support systems are widely used in pediatric care. The aim of this study was to assess the support for drug treatments used at pediatric cardiac wards and intensive care units in Sweden. Methods: Drug information, such as type of drug, indication, dose, and route of administration, for all in-hospital pediatric cardiac patients, was included in the study. Treatments were classified as either on-label (based on product information) or off-label. Support for off-label treatment was stratified by the use of clinical support systems (the national database on drugs, local, or other clinical experience guidelines). Results: In all, 28 patients were included in the study. The total number of drug treatments was 233, encompassing 65 different drugs. Overall, 175 (75%) treatments were off-label. A majority of off-label drug treatments were supported by other sources of information shared by experts. A total of 7% of the drug treatments were used without support. Conclusion: Off-label drug treatment is still common in Swedish pediatric cardiac care. However, the majority of treatments were supported by the experience shared in clinical support systems. Key Points: Seventy-five percent of all prescriptions in pediatric cardiology care were off-label. A majority of patients received three or more drug treatments off-label. Use of clinical support systems and guidelines was common, but in 7% of all drug treatments, no support was found for the chosen treatment.</p>}},
  author       = {{Back, Julia and Wåhlander, Håkan and Hanseus, Katarina and Bergman, Gunnar and Naumburg, Estelle}},
  issn         = {{2398-8835}},
  keywords     = {{drugs; medical support systems; off-label; pediatric cardiology; pediatrics}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Health Science Reports}},
  title        = {{Evidence of support used for drug treatments in pediatric cardiology}},
  url          = {{http://dx.doi.org/10.1002/hsr2.288}},
  doi          = {{10.1002/hsr2.288}},
  volume       = {{4}},
  year         = {{2021}},
}