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Insulin resistance is inversely related to prostate cancer : A prospective study in Northern Sweden

Stocks, Tanja LU ; Lukanova, Annekatrin ; Rinaldi, Sabina ; Biessy, Carine ; Dossus, Laure ; Lindahl, Bernt ; Hallmans, Göran ; Kaaks, Rudolf and Stattin, Pär (2007) In International Journal of Cancer 120(12). p.2678-2686
Abstract

Factors related to insulin resistance have been implicated in prostate cancer development, however, few analytical studies support such an association. We performed a case control study on 392 prostate cancer cases and 392 matched controls nested in a prospective cohort in Northern Sweden. Plasma concentrations of C-peptide, leptin, glycated haemoglobin (HbA1c) and fasting and post-load glucose were analysed and homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Conditional logistic regression analyses were used to calculate odds ratios (OR) of prostate cancer. High levels of C-peptide, HOMA-IR, leptin and HbA1c were associated with significant decreases in risk of prostate cancer, with ORs for top vs. bottom... (More)

Factors related to insulin resistance have been implicated in prostate cancer development, however, few analytical studies support such an association. We performed a case control study on 392 prostate cancer cases and 392 matched controls nested in a prospective cohort in Northern Sweden. Plasma concentrations of C-peptide, leptin, glycated haemoglobin (HbA1c) and fasting and post-load glucose were analysed and homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Conditional logistic regression analyses were used to calculate odds ratios (OR) of prostate cancer. High levels of C-peptide, HOMA-IR, leptin and HbA1c were associated with significant decreases in risk of prostate cancer, with ORs for top vs. bottom quartile for C-peptide of 0.59 (95% Confidence Interval [CI], 0.40-0.89; ptrend = 0.008), HOMA-IR 0.60 (95% CI, 0.38-0.94; ptrend = 0.03), leptin 0.55 (95% CI, 0.36-0.84; ptrend = 0.006) and HbA1c 0.56 (95% CI, 0.35-0.91; p trend = 0.02). All studied factors were strongly inversely related to risk among men less than 59 years of age at blood sampling, but not among older men, with a significant heterogeneity between the groups for leptin (p heterogeneity = 0.006) and fasting glucose (pheterogeneity = 0.03). C-peptide and HOMA-IR were strongly inversely related to non-aggressive cancer but were non-significantly positively related to risk of aggressive disease (pheterogeneity = 0.007 and 0.01, respectively). Our data suggest that androgens, which are inversely associated with insulin resistance, are important in the early prostate cancer development, whereas insulin resistance related factors may be important for tumour progression.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood glucose, C-peptide, Insulin resistance, Leptin, Prostatic neoplasms
in
International Journal of Cancer
volume
120
issue
12
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:34247519153
  • pmid:17278097
ISSN
0020-7136
DOI
10.1002/ijc.22587
language
English
LU publication?
no
id
f34a581b-5f63-4004-a518-b4b75f257bed
date added to LUP
2019-05-31 09:25:01
date last changed
2020-01-13 01:56:49
@article{f34a581b-5f63-4004-a518-b4b75f257bed,
  abstract     = {<p>Factors related to insulin resistance have been implicated in prostate cancer development, however, few analytical studies support such an association. We performed a case control study on 392 prostate cancer cases and 392 matched controls nested in a prospective cohort in Northern Sweden. Plasma concentrations of C-peptide, leptin, glycated haemoglobin (HbA1c) and fasting and post-load glucose were analysed and homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Conditional logistic regression analyses were used to calculate odds ratios (OR) of prostate cancer. High levels of C-peptide, HOMA-IR, leptin and HbA1c were associated with significant decreases in risk of prostate cancer, with ORs for top vs. bottom quartile for C-peptide of 0.59 (95% Confidence Interval [CI], 0.40-0.89; p<sub>trend</sub> = 0.008), HOMA-IR 0.60 (95% CI, 0.38-0.94; p<sub>trend</sub> = 0.03), leptin 0.55 (95% CI, 0.36-0.84; p<sub>trend</sub> = 0.006) and HbA1c 0.56 (95% CI, 0.35-0.91; p <sub>trend</sub> = 0.02). All studied factors were strongly inversely related to risk among men less than 59 years of age at blood sampling, but not among older men, with a significant heterogeneity between the groups for leptin (p <sub>heterogeneity</sub> = 0.006) and fasting glucose (p<sub>heterogeneity</sub> = 0.03). C-peptide and HOMA-IR were strongly inversely related to non-aggressive cancer but were non-significantly positively related to risk of aggressive disease (p<sub>heterogeneity</sub> = 0.007 and 0.01, respectively). Our data suggest that androgens, which are inversely associated with insulin resistance, are important in the early prostate cancer development, whereas insulin resistance related factors may be important for tumour progression.</p>},
  author       = {Stocks, Tanja and Lukanova, Annekatrin and Rinaldi, Sabina and Biessy, Carine and Dossus, Laure and Lindahl, Bernt and Hallmans, Göran and Kaaks, Rudolf and Stattin, Pär},
  issn         = {0020-7136},
  language     = {eng},
  month        = {06},
  number       = {12},
  pages        = {2678--2686},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Insulin resistance is inversely related to prostate cancer : A prospective study in Northern Sweden},
  url          = {http://dx.doi.org/10.1002/ijc.22587},
  doi          = {10.1002/ijc.22587},
  volume       = {120},
  year         = {2007},
}