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Increased fat mass index is associated with decreased glomerular filtration rate estimated from cystatin C. Data from Malmö Diet and Cancer cohort

Laucyte-Cibulskiene, Agne LU orcid ; Nilsson, Peter M. LU ; Engström, Gunnar LU and Christensson, Anders LU (2022) In PLoS ONE 17(7 July).
Abstract

Background This study aims to describe associations of obesity and CKD in a Swedish urban population. The impact of fat mass, from bioimpedance analysis, on eGFR based on cystatin C and/or creatinine is studied. Methods 5049 participants from Malmö Diet and Cancer Study the cardiovascular arm (MDCS-CV) with available body mass composition (single frequency bioimpedance analysis) and cystatin C measured at baseline were selected. Body mass index (kg/m2) was used to define overweight/obesity. eGFR was calculated using cystatin C (eGFRCYS) and creatinine (eGFRCR) equations: Chronic Kidney Disease Epidemiology Collaboration 2012 (CKD-EPICR, CKD-EPICYS, CKD-EPICR-CYS)... (More)

Background This study aims to describe associations of obesity and CKD in a Swedish urban population. The impact of fat mass, from bioimpedance analysis, on eGFR based on cystatin C and/or creatinine is studied. Methods 5049 participants from Malmö Diet and Cancer Study the cardiovascular arm (MDCS-CV) with available body mass composition (single frequency bioimpedance analysis) and cystatin C measured at baseline were selected. Body mass index (kg/m2) was used to define overweight/obesity. eGFR was calculated using cystatin C (eGFRCYS) and creatinine (eGFRCR) equations: Chronic Kidney Disease Epidemiology Collaboration 2012 (CKD-EPICR, CKD-EPICYS, CKD-EPICR-CYS) eGFRCYS based on Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised equation (LMrev), and Modified Full Age Spectrum creatinine-based equation (EKFCCR). Two different fat mass index (FMI) z-scores were calculated: FMI z-scoreLarsson and FMI z-scoreLee. Results Lower eGFRCYS and eGFRCR-CYS following multiple adjustments were prevalent in overweight/obese subjects. Increase in FMI z-scoreLarsson or FMI z-scoreLee was related to decrease in predicted CAPA, CKD-EPICYS, CKD-EPICR-CYS and CAPA-LMrev equation. Conclusion eGFRCYS, in contrast to combined eGFRCR-CYS and eGFRCR, demonstrate the strongest association between FMI and kidney function.

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organization
publishing date
type
Contribution to journal
publication status
published
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in
PLoS ONE
volume
17
issue
7 July
article number
e0271638
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:35862349
  • scopus:85134817222
ISSN
1932-6203
DOI
10.1371/journal.pone.0271638
language
English
LU publication?
yes
id
f36790d8-14b1-4418-afe3-9b1467c5b8f7
date added to LUP
2022-09-05 15:08:44
date last changed
2025-03-07 21:07:26
@article{f36790d8-14b1-4418-afe3-9b1467c5b8f7,
  abstract     = {{<p>Background This study aims to describe associations of obesity and CKD in a Swedish urban population. The impact of fat mass, from bioimpedance analysis, on eGFR based on cystatin C and/or creatinine is studied. Methods 5049 participants from Malmö Diet and Cancer Study the cardiovascular arm (MDCS-CV) with available body mass composition (single frequency bioimpedance analysis) and cystatin C measured at baseline were selected. Body mass index (kg/m<sup>2</sup>) was used to define overweight/obesity. eGFR was calculated using cystatin C (eGFR<sub>CYS</sub>) and creatinine (eGFR<sub>CR</sub>) equations: Chronic Kidney Disease Epidemiology Collaboration 2012 (CKD-EPI<sub>CR,</sub> CKD-EPI<sub>CYS</sub>, CKD-EPI<sub>CR-CYS</sub>) eGFR<sub>CYS</sub> based on Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised equation (LMrev), and Modified Full Age Spectrum creatinine-based equation (EKFC<sub>CR</sub>). Two different fat mass index (FMI) z-scores were calculated: FMI z-score<sub>Larsson</sub> and FMI z-score<sub>Lee</sub>. Results Lower eGFR<sub>CYS</sub> and eGFR<sub>CR-CYS</sub> following multiple adjustments were prevalent in overweight/obese subjects. Increase in FMI z-score<sub>Larsson</sub> or FMI z-score<sub>Lee</sub> was related to decrease in predicted CAPA, CKD-EPI<sub>CYS</sub>, CKD-EPI<sub>CR-CYS</sub> and CAPA-LMrev equation. Conclusion eGFR<sub>CYS</sub>, in contrast to combined eGFR<sub>CR-CYS</sub> and eGFR<sub>CR</sub>, demonstrate the strongest association between FMI and kidney function.</p>}},
  author       = {{Laucyte-Cibulskiene, Agne and Nilsson, Peter M. and Engström, Gunnar and Christensson, Anders}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{7 July}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Increased fat mass index is associated with decreased glomerular filtration rate estimated from cystatin C. Data from Malmö Diet and Cancer cohort}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0271638}},
  doi          = {{10.1371/journal.pone.0271638}},
  volume       = {{17}},
  year         = {{2022}},
}