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Developing a framework for studying brain networks in neonatal hypoxic-ischemic encephalopathy

Lennartsson, Finn LU ; Darekar, Angela ; Maharatna, Koushik ; Konn, Daniel ; Allen, David ; Tournier, J. Donald ; Broulidakis, John and Vollmer, Brigitte (2018) 22nd Conference on Medical Image Understanding and Analysis, MIUA 2018 In Communications in Computer and Information Science 894. p.203-216
Abstract

Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment. Neural correlates of cognitive and behavioral impairment in neonatal HIE, in particular in infants who survive without severe neuromotor impairment, are poorly understood. It is reasonable to hypothesize that in HIE both structural and functional brain networks are altered, and that this might be the neural correlate of impaired cognitive and/or behavioral impairment in HIE. Here, an analysis pipeline to study the structural and functional brain networks from neonatal MRI in newborns with HIE is presented. The structural connectivity is generated... (More)

Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment. Neural correlates of cognitive and behavioral impairment in neonatal HIE, in particular in infants who survive without severe neuromotor impairment, are poorly understood. It is reasonable to hypothesize that in HIE both structural and functional brain networks are altered, and that this might be the neural correlate of impaired cognitive and/or behavioral impairment in HIE. Here, an analysis pipeline to study the structural and functional brain networks from neonatal MRI in newborns with HIE is presented. The structural connectivity is generated from dense whole-brain tractograms derived from diffusion-weighted MR fibre tractography. This investigation of functional connectivity focuses on the emerging resting state networks (RSNs), which are sensitive to injuries from hypoxic-ischemic insults to the newborn brain. In conjunction with the structural connectivity, alterations to the structuro-functional connectivity of the RSNs can be studied. Preliminary results from a proof-of-concept study in a small cohort of newborns with HIE are promising. The obstacles encountered and improvements to the pipeline are discussed. The framework can be further extended for joint analysis with EEG functional-connectivity.

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author
; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Connectivity, Diffusion MRI, Human brain, Hypoxic-ischemic encephalopathy, Networks, Resting-state functional MRI
host publication
Medical Image Understanding and Analysis - 22nd Conference, Proceedings
series title
Communications in Computer and Information Science
editor
Nixon, Mark ; Mahmoodi, Sasan and Zwiggelaar, Reyer
volume
894
pages
14 pages
publisher
Springer
conference name
22nd Conference on Medical Image Understanding and Analysis, MIUA 2018
conference location
Southampton, United Kingdom
conference dates
2018-07-09 - 2018-07-11
external identifiers
  • scopus:85052905508
ISSN
1865-0929
ISBN
9783319959207
DOI
10.1007/978-3-319-95921-4_20
language
English
LU publication?
yes
id
f37db3bc-d872-4fb4-876f-359058768c43
date added to LUP
2018-10-29 12:35:00
date last changed
2021-08-18 01:50:22
@inproceedings{f37db3bc-d872-4fb4-876f-359058768c43,
  abstract     = {<p>Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment. Neural correlates of cognitive and behavioral impairment in neonatal HIE, in particular in infants who survive without severe neuromotor impairment, are poorly understood. It is reasonable to hypothesize that in HIE both structural and functional brain networks are altered, and that this might be the neural correlate of impaired cognitive and/or behavioral impairment in HIE. Here, an analysis pipeline to study the structural and functional brain networks from neonatal MRI in newborns with HIE is presented. The structural connectivity is generated from dense whole-brain tractograms derived from diffusion-weighted MR fibre tractography. This investigation of functional connectivity focuses on the emerging resting state networks (RSNs), which are sensitive to injuries from hypoxic-ischemic insults to the newborn brain. In conjunction with the structural connectivity, alterations to the structuro-functional connectivity of the RSNs can be studied. Preliminary results from a proof-of-concept study in a small cohort of newborns with HIE are promising. The obstacles encountered and improvements to the pipeline are discussed. The framework can be further extended for joint analysis with EEG functional-connectivity.</p>},
  author       = {Lennartsson, Finn and Darekar, Angela and Maharatna, Koushik and Konn, Daniel and Allen, David and Tournier, J. Donald and Broulidakis, John and Vollmer, Brigitte},
  booktitle    = {Medical Image Understanding and Analysis - 22nd Conference, Proceedings},
  editor       = {Nixon, Mark and Mahmoodi, Sasan and Zwiggelaar, Reyer},
  isbn         = {9783319959207},
  issn         = {1865-0929},
  language     = {eng},
  month        = {01},
  pages        = {203--216},
  publisher    = {Springer},
  series       = {Communications in Computer and Information Science},
  title        = {Developing a framework for studying brain networks in neonatal hypoxic-ischemic encephalopathy},
  url          = {http://dx.doi.org/10.1007/978-3-319-95921-4_20},
  doi          = {10.1007/978-3-319-95921-4_20},
  volume       = {894},
  year         = {2018},
}