STRUCTURAL BASIS OF SH2 DOMAIN MUTATIONS IN X-LINKED AGAMMAGLOBULINEMIA
Vihinen, Mauno LU
; NILSSON, L
and SMITH, CIE
(1994)
In Biochemical and Biophysical Research Communications
205(2).
p.1270-1277
- Abstract
- The three-dimensional structure of Bruton's agammaloglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target protein, which probably is YEXI/L. Mutations in the Btk sequence can cause the human disease X-linked agammaglobulinemia and reasons for the disease in Btk SH2 mutations were inferred from the model. (C) 1994 Academic Press, Inc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3853337
- author
- Vihinen, Mauno
LU
; NILSSON, L
and SMITH, CIE
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical and Biophysical Research Communications
- volume
- 205
- issue
- 2
- pages
- 1270 - 1277
- publisher
- Elsevier
- external identifiers
-
- wos:A1994PY70600041
- scopus:0028641301
- ISSN
- 1090-2104
- DOI
- 10.1006/bbrc.1994.2802
- language
- English
- LU publication?
- no
- id
- f389173a-85b3-4b8c-af15-7d63d53e6829 (old id 3853337)
- date added to LUP
- 2016-04-01 16:38:04
- date last changed
- 2021-01-03 06:12:10
@article{f389173a-85b3-4b8c-af15-7d63d53e6829,
abstract = {{The three-dimensional structure of Bruton's agammaloglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target protein, which probably is YEXI/L. Mutations in the Btk sequence can cause the human disease X-linked agammaglobulinemia and reasons for the disease in Btk SH2 mutations were inferred from the model. (C) 1994 Academic Press, Inc.}},
author = {{Vihinen, Mauno and NILSSON, L and SMITH, CIE}},
issn = {{1090-2104}},
language = {{eng}},
number = {{2}},
pages = {{1270--1277}},
publisher = {{Elsevier}},
series = {{Biochemical and Biophysical Research Communications}},
title = {{STRUCTURAL BASIS OF SH2 DOMAIN MUTATIONS IN X-LINKED AGAMMAGLOBULINEMIA}},
url = {{http://dx.doi.org/10.1006/bbrc.1994.2802}},
doi = {{10.1006/bbrc.1994.2802}},
volume = {{205}},
year = {{1994}},
}