Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

A harmonized segmentation protocol for hippocampal and parahippocampal subregions : Why do we need one and what are the key goals?

Wisse, Laura E M LU orcid ; Daugherty, Ana M ; Olsen, Rosanna K ; Berron, David LU ; Carr, Valerie A ; Stark, Craig E L ; Amaral, Robert S C ; Amunts, Katrin ; Augustinack, Jean C and Bender, Andrew R , et al. (2017) In Hippocampus 27(1). p.3-11
Abstract

The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include... (More)

The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, striking the right balance between reliability of measurements and anatomical validity, and the development of a versatile protocol that can be adopted for the study of populations varying in age and health. The commentary outlines these key challenges, as well as the proposed solution of each, with concrete examples from our working plan. Finally, with two examples, we illustrate how the harmonized protocol, once completed, is expected to impact the field by producing measurements that are quantitatively comparable across labs and by facilitating the synthesis of findings across different studies. © 2016 Wiley Periodicals, Inc.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
author collaboration
publishing date
type
Contribution to journal
publication status
published
keywords
Hippocampus/diagnostic imaging, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Parahippocampal Gyrus/diagnostic imaging, Pattern Recognition, Automated
in
Hippocampus
volume
27
issue
1
pages
3 - 11
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:27862600
  • scopus:85003698517
ISSN
1050-9631
DOI
10.1002/hipo.22671
language
English
LU publication?
no
additional info
© 2016 Wiley Periodicals, Inc.
id
f39139de-1407-4a05-856f-6674134b944e
date added to LUP
2024-02-28 14:55:48
date last changed
2024-05-12 03:34:45
@article{f39139de-1407-4a05-856f-6674134b944e,
  abstract     = {{<p>The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, striking the right balance between reliability of measurements and anatomical validity, and the development of a versatile protocol that can be adopted for the study of populations varying in age and health. The commentary outlines these key challenges, as well as the proposed solution of each, with concrete examples from our working plan. Finally, with two examples, we illustrate how the harmonized protocol, once completed, is expected to impact the field by producing measurements that are quantitatively comparable across labs and by facilitating the synthesis of findings across different studies. © 2016 Wiley Periodicals, Inc.</p>}},
  author       = {{Wisse, Laura E M and Daugherty, Ana M and Olsen, Rosanna K and Berron, David and Carr, Valerie A and Stark, Craig E L and Amaral, Robert S C and Amunts, Katrin and Augustinack, Jean C and Bender, Andrew R and Bernstein, Jeffrey D and Boccardi, Marina and Bocchetta, Martina and Burggren, Alison and Chakravarty, M Mallar and Chupin, Marie and Ekstrom, Arne and de Flores, Robin and Insausti, Ricardo and Kanel, Prabesh and Kedo, Olga and Kennedy, Kristen M and Kerchner, Geoffrey A and LaRocque, Karen F and Liu, Xiuwen and Maass, Anne and Malykhin, Nicolai and Mueller, Susanne G and Ofen, Noa and Palombo, Daniela J and Parekh, Mansi B and Pluta, John B and Pruessner, Jens C and Raz, Naftali and Rodrigue, Karen M and Schoemaker, Dorothee and Shafer, Andrea T and Steve, Trevor A and Suthana, Nanthia and Wang, Lei and Winterburn, Julie L and Yassa, Michael A and Yushkevich, Paul A and la Joie, Renaud}},
  issn         = {{1050-9631}},
  keywords     = {{Hippocampus/diagnostic imaging; Humans; Image Processing, Computer-Assisted/methods; Magnetic Resonance Imaging/methods; Parahippocampal Gyrus/diagnostic imaging; Pattern Recognition, Automated}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{3--11}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Hippocampus}},
  title        = {{A harmonized segmentation protocol for hippocampal and parahippocampal subregions : Why do we need one and what are the key goals?}},
  url          = {{http://dx.doi.org/10.1002/hipo.22671}},
  doi          = {{10.1002/hipo.22671}},
  volume       = {{27}},
  year         = {{2017}},
}