Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease
de Flores, Robin ; Wisse, Laura E M LU
; Das, Sandhitsu R
; Xie, Long
; McMillan, Corey T
; Trojanowski, John Q
; Robinson, John L
; Grossman, Murray
; Lee, Edward
and Irwin, David J
, et al.
(2020)
In Alzheimer's & dementia : the journal of the Alzheimer's Association
16(6).
p.843-852
- Abstract
INTRODUCTION: It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).
METHODS: We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of tau, TDP-43, Aβ, and α-synuclein measured in post-mortem tissue from 92 individuals with intermediate to high AD neuropathology. Receiver-operating characteristic (ROC) curves were analyzed for each subregion in order to discriminate TDP-43-negative and TDP-43-positive patients.
RESULTS: TDP-43 was strongly associated with anterior... (More)
INTRODUCTION: It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).
METHODS: We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of tau, TDP-43, Aβ, and α-synuclein measured in post-mortem tissue from 92 individuals with intermediate to high AD neuropathology. Receiver-operating characteristic (ROC) curves were analyzed for each subregion in order to discriminate TDP-43-negative and TDP-43-positive patients.
RESULTS: TDP-43 was strongly associated with anterior MTL regions, whereas tau was relatively more associated with the posterior hippocampus. Among the MTL regions, the anterior hippocampus showed the highest area under the ROC curve (AUC).
DISCUSSION: We found specific contributions of different pathologies on MTL substructure in this population with AD neuropathology. The anterior hippocampus may be a relevant region to detect concomitant TDP-43 pathology in the MTL of patients with AD.
(Less)
- author
- de Flores, Robin
; Wisse, Laura E M
LU
; Das, Sandhitsu R
; Xie, Long
; McMillan, Corey T
; Trojanowski, John Q
; Robinson, John L
; Grossman, Murray
; Lee, Edward
and Irwin, David J
, et al. (More)
- de Flores, Robin
; Wisse, Laura E M
LU
; Das, Sandhitsu R
; Xie, Long
; McMillan, Corey T
; Trojanowski, John Q
; Robinson, John L
; Grossman, Murray
; Lee, Edward
; Irwin, David J
; Yushkevich, Paul A
and Wolk, David A
(Less)
- publishing date
- 2020-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Alzheimer Disease/diagnostic imaging, Amyloid beta-Peptides/metabolism, Atrophy/diagnostic imaging, DNA-Binding Proteins/metabolism, Humans, Magnetic Resonance Imaging, Temporal Lobe/diagnostic imaging, alpha-Synuclein/metabolism, tau Proteins/metabolism
- in
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- volume
- 16
- issue
- 6
- pages
- 10 pages
- publisher
- Wiley
- external identifiers
-
- pmid:32323446
- scopus:85083858277
- ISSN
- 1552-5279
- DOI
- 10.1002/alz.12079
- language
- English
- LU publication?
- no
- additional info
- © 2020 the Alzheimer's Association.
- id
- f3c46ad4-dc9d-4e0e-9153-b1cb657b817f
- date added to LUP
- 2022-05-30 13:35:14
- date last changed
- 2024-06-14 07:01:21
@article{f3c46ad4-dc9d-4e0e-9153-b1cb657b817f,
abstract = {{<p>INTRODUCTION: It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).</p><p>METHODS: We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of tau, TDP-43, Aβ, and α-synuclein measured in post-mortem tissue from 92 individuals with intermediate to high AD neuropathology. Receiver-operating characteristic (ROC) curves were analyzed for each subregion in order to discriminate TDP-43-negative and TDP-43-positive patients.</p><p>RESULTS: TDP-43 was strongly associated with anterior MTL regions, whereas tau was relatively more associated with the posterior hippocampus. Among the MTL regions, the anterior hippocampus showed the highest area under the ROC curve (AUC).</p><p>DISCUSSION: We found specific contributions of different pathologies on MTL substructure in this population with AD neuropathology. The anterior hippocampus may be a relevant region to detect concomitant TDP-43 pathology in the MTL of patients with AD.</p>}},
author = {{de Flores, Robin and Wisse, Laura E M and Das, Sandhitsu R and Xie, Long and McMillan, Corey T and Trojanowski, John Q and Robinson, John L and Grossman, Murray and Lee, Edward and Irwin, David J and Yushkevich, Paul A and Wolk, David A}},
issn = {{1552-5279}},
keywords = {{Alzheimer Disease/diagnostic imaging; Amyloid beta-Peptides/metabolism; Atrophy/diagnostic imaging; DNA-Binding Proteins/metabolism; Humans; Magnetic Resonance Imaging; Temporal Lobe/diagnostic imaging; alpha-Synuclein/metabolism; tau Proteins/metabolism}},
language = {{eng}},
number = {{6}},
pages = {{843--852}},
publisher = {{Wiley}},
series = {{Alzheimer's & dementia : the journal of the Alzheimer's Association}},
title = {{Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease}},
url = {{http://dx.doi.org/10.1002/alz.12079}},
doi = {{10.1002/alz.12079}},
volume = {{16}},
year = {{2020}},
}