Advanced

NDDVD : an integrated and manually curated Neurodegenerative Diseases Variation Database

Yang, Yang LU ; Xu, Chen ; Liu, Xingyun ; Xu, Chao ; Zhang, Yuanyuan ; Shen, Li ; Vihinen, Mauno LU and Shen, Bairong (2018) In Database : the journal of biological databases and curation 2018.
Abstract

Neurodegenerative diseases (NDDs) are associated with genetic variations
including point substitutions, copy number alterations, insertions and
deletions. At present, a few genetic variation repositories for some
individual NDDs have been created, however, these databases are needed
to be integrated and expanded to all the NDDs for systems biological
investigation. We here build a relational database termed as NDDVD to
integrate all the variations of NDDs using Leiden Open Variation
Database (LOVD) platform. The items in the NDDVD are collected manually
from PubMed or extracted from the existed variation databases. The
cross-disease database includes over 6374 genetic variations of 289
... (More)

Neurodegenerative diseases (NDDs) are associated with genetic variations
including point substitutions, copy number alterations, insertions and
deletions. At present, a few genetic variation repositories for some
individual NDDs have been created, however, these databases are needed
to be integrated and expanded to all the NDDs for systems biological
investigation. We here build a relational database termed as NDDVD to
integrate all the variations of NDDs using Leiden Open Variation
Database (LOVD) platform. The items in the NDDVD are collected manually
from PubMed or extracted from the existed variation databases. The
cross-disease database includes over 6374 genetic variations of 289
genes associated with 37 different NDDs. The patterns, conservations and
biological functions for variations in different NDDs are statistically
compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Database : the journal of biological databases and curation
volume
2018
article number
bay018
publisher
Oxford University Press
external identifiers
  • pmid:29688368
  • scopus:85054772621
ISSN
1758-0463
DOI
10.1093/database/bay018
language
English
LU publication?
yes
id
f3cadaaa-9a01-42c2-b059-d774a6bfd51d
date added to LUP
2018-11-13 12:30:01
date last changed
2020-10-20 04:18:00
@article{f3cadaaa-9a01-42c2-b059-d774a6bfd51d,
  abstract     = {<p>Neurodegenerative diseases (NDDs) are associated with genetic variations<br>
 including point substitutions, copy number alterations, insertions and <br>
deletions. At present, a few genetic variation repositories for some <br>
individual NDDs have been created, however, these databases are needed <br>
to be integrated and expanded to all the NDDs for systems biological <br>
investigation. We here build a relational database termed as NDDVD to <br>
integrate all the variations of NDDs using Leiden Open Variation <br>
Database (LOVD) platform. The items in the NDDVD are collected manually <br>
from PubMed or extracted from the existed variation databases. The <br>
cross-disease database includes over 6374 genetic variations of 289 <br>
genes associated with 37 different NDDs. The patterns, conservations and<br>
 biological functions for variations in different NDDs are statistically<br>
 compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.</p>},
  author       = {Yang, Yang and Xu, Chen and Liu, Xingyun and Xu, Chao and Zhang, Yuanyuan and Shen, Li and Vihinen, Mauno and Shen, Bairong},
  issn         = {1758-0463},
  language     = {eng},
  month        = {01},
  publisher    = {Oxford University Press},
  series       = {Database : the journal of biological databases and curation},
  title        = {NDDVD : an integrated and manually curated Neurodegenerative Diseases Variation Database},
  url          = {http://dx.doi.org/10.1093/database/bay018},
  doi          = {10.1093/database/bay018},
  volume       = {2018},
  year         = {2018},
}