Low serum concentration of all-trans and 13-cis retinoic acids in patients treated with phenytoin, carbamazepine and valproate. Possible relation to teratogenicity
(1995) In Archives of Toxicology 69(8). p.572-574- Abstract
- All-trans retinoic acid deficiency resulting from ethanol's interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome. Phenytoin, carbamazepine and valproate, might be teratogenic because they lower the concentration of all-trans retinoic acid in serum, by inducing the enzyme systems in the liver responsible for the metabolism of the all-trans retinoic acid, or by other mechanisms. Here we show, that in patients given therapeutic doses of phenytoin, carbamazepine and valproate, serum all-trans and 13-cis retinoic acid concentrations are indeed significantly lowered. We propose that drugs with this ability should be considered as potential... (More)
- All-trans retinoic acid deficiency resulting from ethanol's interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome. Phenytoin, carbamazepine and valproate, might be teratogenic because they lower the concentration of all-trans retinoic acid in serum, by inducing the enzyme systems in the liver responsible for the metabolism of the all-trans retinoic acid, or by other mechanisms. Here we show, that in patients given therapeutic doses of phenytoin, carbamazepine and valproate, serum all-trans and 13-cis retinoic acid concentrations are indeed significantly lowered. We propose that drugs with this ability should be considered as potential teratogens. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109014
- author
- Fex, G ; Larsson, K ; Andersson, A and Berggren Söderlund, Maria LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Retinoic acid, Phenytoin, Carbamazepin, Valproate, Teratogenicity
- in
- Archives of Toxicology
- volume
- 69
- issue
- 8
- pages
- 572 - 574
- publisher
- Springer
- external identifiers
-
- pmid:8534203
- scopus:0029156849
- ISSN
- 0340-5761
- DOI
- 10.1007/s002040050215
- language
- English
- LU publication?
- yes
- id
- f444554b-9549-4cfc-b631-2a51c00d6f6e (old id 1109014)
- date added to LUP
- 2016-04-01 16:26:15
- date last changed
- 2021-08-29 04:31:10
@article{f444554b-9549-4cfc-b631-2a51c00d6f6e,
abstract = {{All-trans retinoic acid deficiency resulting from ethanol's interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome. Phenytoin, carbamazepine and valproate, might be teratogenic because they lower the concentration of all-trans retinoic acid in serum, by inducing the enzyme systems in the liver responsible for the metabolism of the all-trans retinoic acid, or by other mechanisms. Here we show, that in patients given therapeutic doses of phenytoin, carbamazepine and valproate, serum all-trans and 13-cis retinoic acid concentrations are indeed significantly lowered. We propose that drugs with this ability should be considered as potential teratogens.}},
author = {{Fex, G and Larsson, K and Andersson, A and Berggren Söderlund, Maria}},
issn = {{0340-5761}},
keywords = {{Retinoic acid; Phenytoin; Carbamazepin; Valproate; Teratogenicity}},
language = {{eng}},
number = {{8}},
pages = {{572--574}},
publisher = {{Springer}},
series = {{Archives of Toxicology}},
title = {{Low serum concentration of all-trans and 13-cis retinoic acids in patients treated with phenytoin, carbamazepine and valproate. Possible relation to teratogenicity}},
url = {{http://dx.doi.org/10.1007/s002040050215}},
doi = {{10.1007/s002040050215}},
volume = {{69}},
year = {{1995}},
}