The spectrum of diseases causing fever of unknown origin in Turkey : a multicenter study
(2008) In International Journal of Infectious Diseases 12(1). p.9-71- Abstract
OBJECTIVE: The purpose of this trial was to determine the spectrum of diseases with fever of unknown origin (FUO) in Turkey.
METHODS: A prospective multicenter study of 154 patients with FUO in twelve Turkish tertiary-care hospitals was conducted.
RESULTS: The mean age of the patients was 42+/-17 years (range 17-75). Fifty-three (34.4%) had infectious diseases (ID), 47 (30.5%) had non-infectious inflammatory diseases (NIID), 22 (14.3%) had malignant diseases (MD), and eight (5.2%) had miscellaneous diseases (Mi). In 24 (15.6%) of the cases, the reason for high fever could not be determined despite intensive efforts. The most common ID etiologies were tuberculosis (13.6%) and cytomegalovirus (CMV) infection (3.2%). Adult... (More)
OBJECTIVE: The purpose of this trial was to determine the spectrum of diseases with fever of unknown origin (FUO) in Turkey.
METHODS: A prospective multicenter study of 154 patients with FUO in twelve Turkish tertiary-care hospitals was conducted.
RESULTS: The mean age of the patients was 42+/-17 years (range 17-75). Fifty-three (34.4%) had infectious diseases (ID), 47 (30.5%) had non-infectious inflammatory diseases (NIID), 22 (14.3%) had malignant diseases (MD), and eight (5.2%) had miscellaneous diseases (Mi). In 24 (15.6%) of the cases, the reason for high fever could not be determined despite intensive efforts. The most common ID etiologies were tuberculosis (13.6%) and cytomegalovirus (CMV) infection (3.2%). Adult Still's disease was the most common NIID (13.6%) and hematological malignancy was the most common MD (7.8%). In patients with NIID, the mean duration of reaching a definite diagnosis (37+/-23 days) was significantly longer compared to the patients with ID (25+/-12 days) (p=0.007). In patients with MD, the mean duration of fever (51+/-35 days) was longer compared to patients with ID (37+/-38 days) (p=0.052).
CONCLUSIONS: Although infection remains the most common cause of FUO, with the highest percentage for tuberculosis, non-infectious etiologies seem to have increased when compared with previous studies.
(Less)
- author
- author collaboration
- publishing date
- 2008-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Adult, Aged, Communicable Diseases/complications, Female, Fever of Unknown Origin/epidemiology, Hematologic Neoplasms/complications, Humans, Male, Middle Aged, Prospective Studies, Rheumatic Diseases/complications, Turkey/epidemiology
- in
- International Journal of Infectious Diseases
- volume
- 12
- issue
- 1
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:37349007846
- pmid:17629532
- ISSN
- 1201-9712
- DOI
- 10.1016/j.ijid.2007.04.013
- language
- English
- LU publication?
- no
- id
- f448e8e7-0ee8-42df-879f-c15fda9264d3
- date added to LUP
- 2019-06-30 00:40:03
- date last changed
- 2024-06-12 23:03:36
@article{f448e8e7-0ee8-42df-879f-c15fda9264d3,
abstract = {{<p>OBJECTIVE: The purpose of this trial was to determine the spectrum of diseases with fever of unknown origin (FUO) in Turkey.</p><p>METHODS: A prospective multicenter study of 154 patients with FUO in twelve Turkish tertiary-care hospitals was conducted.</p><p>RESULTS: The mean age of the patients was 42+/-17 years (range 17-75). Fifty-three (34.4%) had infectious diseases (ID), 47 (30.5%) had non-infectious inflammatory diseases (NIID), 22 (14.3%) had malignant diseases (MD), and eight (5.2%) had miscellaneous diseases (Mi). In 24 (15.6%) of the cases, the reason for high fever could not be determined despite intensive efforts. The most common ID etiologies were tuberculosis (13.6%) and cytomegalovirus (CMV) infection (3.2%). Adult Still's disease was the most common NIID (13.6%) and hematological malignancy was the most common MD (7.8%). In patients with NIID, the mean duration of reaching a definite diagnosis (37+/-23 days) was significantly longer compared to the patients with ID (25+/-12 days) (p=0.007). In patients with MD, the mean duration of fever (51+/-35 days) was longer compared to patients with ID (37+/-38 days) (p=0.052).</p><p>CONCLUSIONS: Although infection remains the most common cause of FUO, with the highest percentage for tuberculosis, non-infectious etiologies seem to have increased when compared with previous studies.</p>}},
author = {{Kucukardali, Yasar and Oncul, Oral and Cavuslu, Saban and Danaci, Mehmet and Calangu, Semra and Erdem, Hakan and Topcu, Ayse Willke and Adibelli, Zuhal and Akova, Murat and Karaali, Emel Azak and Ozel, Ahmet Melih and Bolaman, Zahit and Caka, Bulent and Cetin, Birsen and Coban, Erkan and Karabay, Oguz and Karakoc, Cagla and Karan, Mehmet Akif and Korkmaz, Selda and Sahin, Gulsen Ozkaya and Pahsa, Alaaddin and Sirmatel, Fatma and Solmazgul, Emrullah and Ozmen, Namik and Tokatli, Ilyas and Uzun, Cengiz and Yakupoglu, Gulsen and Besirbellioglu, Bulent Ahmet and Gul, Hanefi Cem}},
issn = {{1201-9712}},
keywords = {{Adolescent; Adult; Aged; Communicable Diseases/complications; Female; Fever of Unknown Origin/epidemiology; Hematologic Neoplasms/complications; Humans; Male; Middle Aged; Prospective Studies; Rheumatic Diseases/complications; Turkey/epidemiology}},
language = {{eng}},
number = {{1}},
pages = {{9--71}},
publisher = {{Elsevier}},
series = {{International Journal of Infectious Diseases}},
title = {{The spectrum of diseases causing fever of unknown origin in Turkey : a multicenter study}},
url = {{http://dx.doi.org/10.1016/j.ijid.2007.04.013}},
doi = {{10.1016/j.ijid.2007.04.013}},
volume = {{12}},
year = {{2008}},
}