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Isolation of a rat immune response gene identical to an alleged mouse A class II β-chain pseudogene

Schøller, Jørgen and Lernmark, Åke LU orcid (1985) In Immunogenetics 22(6). p.601-608
Abstract

A human HLA-DQ β-chain cDNA was used as a probe to identify and isolate a rat major histocompatibility antigen β-chain gene from a genomic library constructed in the vector λ Charon 28 using Wistar rat DNA (RT1u). The isolated exon of the rat gene (RT1.Bβ2) encoding a β-chain second domain was found to share 93% nucleotide homology with a mouse A β2 exon. Although the genomic organization of this gene is consistent with the hypothesis that it represents a pseudogene, the remarkable preservation of a specific sequence favors the view that this class II antigen β-chain gene has retained its coding function.

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author
and
publishing date
type
Contribution to journal
publication status
published
in
Immunogenetics
volume
22
issue
6
pages
8 pages
publisher
Springer
external identifiers
  • scopus:0022406852
  • pmid:3865893
ISSN
0093-7711
DOI
10.1007/BF00430308
language
English
LU publication?
no
id
f45d0e75-dac6-42d5-8f4b-9ac33009b093
date added to LUP
2019-09-16 12:35:56
date last changed
2024-03-13 08:03:52
@article{f45d0e75-dac6-42d5-8f4b-9ac33009b093,
  abstract     = {{<p>A human HLA-DQ β-chain cDNA was used as a probe to identify and isolate a rat major histocompatibility antigen β-chain gene from a genomic library constructed in the vector λ Charon 28 using Wistar rat DNA (RT1<sup>u</sup>). The isolated exon of the rat gene (RT1.Bβ<sub>2</sub>) encoding a β-chain second domain was found to share 93% nucleotide homology with a mouse A β<sub>2</sub> exon. Although the genomic organization of this gene is consistent with the hypothesis that it represents a pseudogene, the remarkable preservation of a specific sequence favors the view that this class II antigen β-chain gene has retained its coding function.</p>}},
  author       = {{Schøller, Jørgen and Lernmark, Åke}},
  issn         = {{0093-7711}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{6}},
  pages        = {{601--608}},
  publisher    = {{Springer}},
  series       = {{Immunogenetics}},
  title        = {{Isolation of a rat immune response gene identical to an alleged mouse A class II β-chain pseudogene}},
  url          = {{http://dx.doi.org/10.1007/BF00430308}},
  doi          = {{10.1007/BF00430308}},
  volume       = {{22}},
  year         = {{1985}},
}