Isolation of a rat immune response gene identical to an alleged mouse A class II β-chain pseudogene
(1985) In Immunogenetics 22(6). p.601-608- Abstract
A human HLA-DQ β-chain cDNA was used as a probe to identify and isolate a rat major histocompatibility antigen β-chain gene from a genomic library constructed in the vector λ Charon 28 using Wistar rat DNA (RT1u). The isolated exon of the rat gene (RT1.Bβ2) encoding a β-chain second domain was found to share 93% nucleotide homology with a mouse A β2 exon. Although the genomic organization of this gene is consistent with the hypothesis that it represents a pseudogene, the remarkable preservation of a specific sequence favors the view that this class II antigen β-chain gene has retained its coding function.
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https://lup.lub.lu.se/record/f45d0e75-dac6-42d5-8f4b-9ac33009b093
- author
- Schøller, Jørgen and Lernmark, Åke LU
- publishing date
- 1985-12-01
- type
- Contribution to journal
- publication status
- published
- in
- Immunogenetics
- volume
- 22
- issue
- 6
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- pmid:3865893
- scopus:0022406852
- ISSN
- 0093-7711
- DOI
- 10.1007/BF00430308
- language
- English
- LU publication?
- no
- id
- f45d0e75-dac6-42d5-8f4b-9ac33009b093
- date added to LUP
- 2019-09-16 12:35:56
- date last changed
- 2024-03-13 08:03:52
@article{f45d0e75-dac6-42d5-8f4b-9ac33009b093, abstract = {{<p>A human HLA-DQ β-chain cDNA was used as a probe to identify and isolate a rat major histocompatibility antigen β-chain gene from a genomic library constructed in the vector λ Charon 28 using Wistar rat DNA (RT1<sup>u</sup>). The isolated exon of the rat gene (RT1.Bβ<sub>2</sub>) encoding a β-chain second domain was found to share 93% nucleotide homology with a mouse A β<sub>2</sub> exon. Although the genomic organization of this gene is consistent with the hypothesis that it represents a pseudogene, the remarkable preservation of a specific sequence favors the view that this class II antigen β-chain gene has retained its coding function.</p>}}, author = {{Schøller, Jørgen and Lernmark, Åke}}, issn = {{0093-7711}}, language = {{eng}}, month = {{12}}, number = {{6}}, pages = {{601--608}}, publisher = {{Springer}}, series = {{Immunogenetics}}, title = {{Isolation of a rat immune response gene identical to an alleged mouse A class II β-chain pseudogene}}, url = {{http://dx.doi.org/10.1007/BF00430308}}, doi = {{10.1007/BF00430308}}, volume = {{22}}, year = {{1985}}, }