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Tumor Subtyping : Making Sense of Heterogeneity with a Goal Toward Treatment

Meeks, Joshua J. ; Sjödahl, Gottfrid LU ; Lerner, Seth P. ; Das, Arighno ; McConkey, David J. and Black, Peter C. (2021) In Bladder Cancer 7(1). p.1-11
Abstract

BACKGROUND: Bladder cancers have high total mutation burdens resulting in genomic diversity and intra-and inter-tumor heterogeneity that may impact the diversity of gene expression, biologic aggressiveness, and potentially response to therapy. To compare bladder cancers among patients, an organizational structure is necessary that describes the tumor at the histologic and molecular level. These 'molecular subtypes', or 'expression subtypes' of bladder cancer were originally described in 2010 and continue to evolve secondary to next generation sequencing (NGS) and an increasing public repository of well-annotated cohorts. OBJECTIVE: To review the history and methodology of expression-based subtyping of non-muscle invasive (NMIBC) and... (More)

BACKGROUND: Bladder cancers have high total mutation burdens resulting in genomic diversity and intra-and inter-tumor heterogeneity that may impact the diversity of gene expression, biologic aggressiveness, and potentially response to therapy. To compare bladder cancers among patients, an organizational structure is necessary that describes the tumor at the histologic and molecular level. These 'molecular subtypes', or 'expression subtypes' of bladder cancer were originally described in 2010 and continue to evolve secondary to next generation sequencing (NGS) and an increasing public repository of well-annotated cohorts. OBJECTIVE: To review the history and methodology of expression-based subtyping of non-muscle invasive (NMIBC) and muscle invasive bladder cancer (MIBC). METHODS: A literature review was performed of primary papers from PubMed that described subtyping methods and their descriptive feature including search terms of 'subtype', and 'bladder cancer'. RESULTS: 21 papers were identified for review. Tumor subtyping developed from N = 2 to N = 6 subtyping schemes with most subtypes comprised of at least luminal and basal tumors. Most NMIBCs are luminal cancers and luminal MIBCs may be associated with less aggressive features, while one study of basal tumors identified a better clinical outcome with systemic chemotherapy. Tumors with a P53-like may have intrinsic resistance to chemotherapy. The heterogeneity of tumors, which is likely derived from stromal components and immune cell infiltration, affect subtype calls. CONCLUSION: Subtyping, while still evolving, is ready for testing in clinical trials. Improved patient selection with tumor subtyping may help with tumor classification and potentially match patient or tumor to therapy.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bladder cancer, expression-based subtyping, immunology, stroma, systemic therapy
in
Bladder Cancer
volume
7
issue
1
pages
11 pages
publisher
IOS Press
external identifiers
  • scopus:85103057945
ISSN
2352-3727
DOI
10.3233/BLC-200306
language
English
LU publication?
yes
id
f4868346-de57-40ce-a744-ff4df1e1342a
date added to LUP
2021-04-09 08:02:44
date last changed
2022-08-05 08:37:46
@article{f4868346-de57-40ce-a744-ff4df1e1342a,
  abstract     = {{<p>BACKGROUND: Bladder cancers have high total mutation burdens resulting in genomic diversity and intra-and inter-tumor heterogeneity that may impact the diversity of gene expression, biologic aggressiveness, and potentially response to therapy. To compare bladder cancers among patients, an organizational structure is necessary that describes the tumor at the histologic and molecular level. These 'molecular subtypes', or 'expression subtypes' of bladder cancer were originally described in 2010 and continue to evolve secondary to next generation sequencing (NGS) and an increasing public repository of well-annotated cohorts. OBJECTIVE: To review the history and methodology of expression-based subtyping of non-muscle invasive (NMIBC) and muscle invasive bladder cancer (MIBC). METHODS: A literature review was performed of primary papers from PubMed that described subtyping methods and their descriptive feature including search terms of 'subtype', and 'bladder cancer'. RESULTS: 21 papers were identified for review. Tumor subtyping developed from N = 2 to N = 6 subtyping schemes with most subtypes comprised of at least luminal and basal tumors. Most NMIBCs are luminal cancers and luminal MIBCs may be associated with less aggressive features, while one study of basal tumors identified a better clinical outcome with systemic chemotherapy. Tumors with a P53-like may have intrinsic resistance to chemotherapy. The heterogeneity of tumors, which is likely derived from stromal components and immune cell infiltration, affect subtype calls. CONCLUSION: Subtyping, while still evolving, is ready for testing in clinical trials. Improved patient selection with tumor subtyping may help with tumor classification and potentially match patient or tumor to therapy. </p>}},
  author       = {{Meeks, Joshua J. and Sjödahl, Gottfrid and Lerner, Seth P. and Das, Arighno and McConkey, David J. and Black, Peter C.}},
  issn         = {{2352-3727}},
  keywords     = {{Bladder cancer; expression-based subtyping; immunology; stroma; systemic therapy}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--11}},
  publisher    = {{IOS Press}},
  series       = {{Bladder Cancer}},
  title        = {{Tumor Subtyping : Making Sense of Heterogeneity with a Goal Toward Treatment}},
  url          = {{http://dx.doi.org/10.3233/BLC-200306}},
  doi          = {{10.3233/BLC-200306}},
  volume       = {{7}},
  year         = {{2021}},
}