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Abnormal Metabolism of γ-Trace Alkaline Microprotein : The Basic Defect in Hereditary Cerebral Hemorrhage with Amyloidosis

Grubb, Anders LU orcid ; Jensson, Olafur ; Gudmundsson, Gunnar ; Arnason, Alfred ; Löfberg, Helge LU and Malm, Johan LU (1984) In New England Journal of Medicine 311(24). p.1547-1549
Abstract

ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar... (More)

ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
New England Journal of Medicine
volume
311
issue
24
pages
3 pages
publisher
Massachusetts Medical Society
external identifiers
  • scopus:0021706934
  • pmid:6390199
ISSN
0028-4793
DOI
10.1056/NEJM198412133112406
language
English
LU publication?
yes
id
f4cf9fdf-48e8-4533-aa5f-4bd99894625b
date added to LUP
2017-12-11 10:51:00
date last changed
2024-01-14 12:38:31
@article{f4cf9fdf-48e8-4533-aa5f-4bd99894625b,
  abstract     = {{<p>ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.<sup>1</sup><sup>,</sup><sup>2</sup> In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.<sup>3</sup> Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.<sup>4</sup> This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid.</p>}},
  author       = {{Grubb, Anders and Jensson, Olafur and Gudmundsson, Gunnar and Arnason, Alfred and Löfberg, Helge and Malm, Johan}},
  issn         = {{0028-4793}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{24}},
  pages        = {{1547--1549}},
  publisher    = {{Massachusetts Medical Society}},
  series       = {{New England Journal of Medicine}},
  title        = {{Abnormal Metabolism of γ-Trace Alkaline Microprotein : The Basic Defect in Hereditary Cerebral Hemorrhage with Amyloidosis}},
  url          = {{http://dx.doi.org/10.1056/NEJM198412133112406}},
  doi          = {{10.1056/NEJM198412133112406}},
  volume       = {{311}},
  year         = {{1984}},
}