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Time to childbirth and assisted reproductive treatment in women with congenital heart disease

Jonsson, Sara ; Sundström-Poromaa, Inger ; Johansson, Bengt ; Alenius Dahlqvist, Jenny ; Christersson, Christina ; Dellborg, Mikael ; Trzebiatowska-Krzynska, Alexandra ; Sörensson, Peder ; Thilén, Ulf LU and Wikström, Anna Karin , et al. (2024) In Open Heart 11(1).
Abstract

Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio. The time from the 18th birthday to the first childbirth and the prevalence of ART was compared between cases and controls. Results 830 first childbirths in cases were identified and compared with 4137 controls. Cases were slightly older at the time for first... (More)

Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio. The time from the 18th birthday to the first childbirth and the prevalence of ART was compared between cases and controls. Results 830 first childbirths in cases were identified and compared with 4137 controls. Cases were slightly older at the time for first childbirth (28.9 vs 28.5 years, p=0.04) and ART was more common (6.1% vs 4.0%, p<0.01) compared with controls. There were no differences in ART when stratifying for the complexity of CHD. For all women, higher age was associated with ART treatment (OR 1.24, 95% CI 1.20 to 1.28). Conclusions Women with and without CHD who gave birth to a first child did so at similar ages. ART was more common in women with CHD, but disease severity did not influence the need for ART. Age was an important risk factor for ART also in women with CHD and should be considered in consultations with these patients.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, heart defects, congenital, pregnancy
in
Open Heart
volume
11
issue
1
article number
e002591
publisher
BMJ Publishing Group
external identifiers
  • pmid:38485120
  • scopus:85188018449
ISSN
2398-595X
DOI
10.1136/openhrt-2023-002591
language
English
LU publication?
yes
id
f4de10ad-2aa0-4f6a-90c3-c52342e34003
date added to LUP
2024-04-03 09:52:50
date last changed
2024-04-17 12:01:06
@article{f4de10ad-2aa0-4f6a-90c3-c52342e34003,
  abstract     = {{<p>Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio. The time from the 18th birthday to the first childbirth and the prevalence of ART was compared between cases and controls. Results 830 first childbirths in cases were identified and compared with 4137 controls. Cases were slightly older at the time for first childbirth (28.9 vs 28.5 years, p=0.04) and ART was more common (6.1% vs 4.0%, p&lt;0.01) compared with controls. There were no differences in ART when stratifying for the complexity of CHD. For all women, higher age was associated with ART treatment (OR 1.24, 95% CI 1.20 to 1.28). Conclusions Women with and without CHD who gave birth to a first child did so at similar ages. ART was more common in women with CHD, but disease severity did not influence the need for ART. Age was an important risk factor for ART also in women with CHD and should be considered in consultations with these patients.</p>}},
  author       = {{Jonsson, Sara and Sundström-Poromaa, Inger and Johansson, Bengt and Alenius Dahlqvist, Jenny and Christersson, Christina and Dellborg, Mikael and Trzebiatowska-Krzynska, Alexandra and Sörensson, Peder and Thilén, Ulf and Wikström, Anna Karin and Bay, Annika}},
  issn         = {{2398-595X}},
  keywords     = {{epidemiology; heart defects, congenital; pregnancy}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{1}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Open Heart}},
  title        = {{Time to childbirth and assisted reproductive treatment in women with congenital heart disease}},
  url          = {{http://dx.doi.org/10.1136/openhrt-2023-002591}},
  doi          = {{10.1136/openhrt-2023-002591}},
  volume       = {{11}},
  year         = {{2024}},
}