Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
(2005) In Blood 105(4). p.1797-1802- Abstract
- The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 microg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from... (More)
- The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 microg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1132236
- author
- Rivera, Seth ; Liu, Lide ; Nemeth, Elizabeta ; Gabayan, Victoria ; Sørensen, Ole E LU and Ganz, Tomas
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 105
- issue
- 4
- pages
- 1797 - 1802
- publisher
- American Society of Hematology
- external identifiers
-
- pmid:15479721
- scopus:13544252463
- pmid:15479721
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2004-08-3375
- language
- English
- LU publication?
- no
- id
- f4e99571-8d7c-4873-8fed-66ee40b1c6fe (old id 1132236)
- date added to LUP
- 2016-04-01 11:43:31
- date last changed
- 2022-04-05 03:57:44
@article{f4e99571-8d7c-4873-8fed-66ee40b1c6fe,
abstract = {{The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 microg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes.}},
author = {{Rivera, Seth and Liu, Lide and Nemeth, Elizabeta and Gabayan, Victoria and Sørensen, Ole E and Ganz, Tomas}},
issn = {{1528-0020}},
language = {{eng}},
number = {{4}},
pages = {{1797--1802}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia}},
url = {{http://dx.doi.org/10.1182/blood-2004-08-3375}},
doi = {{10.1182/blood-2004-08-3375}},
volume = {{105}},
year = {{2005}},
}