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Smart polymers as surface modifiers for bioanalytical devices and biomaterials : Theory and practice

Ivanov, Alexander E. LU and Zubov, Vitaly P. (2016) In Russian Chemical Reviews 85(6). p.565-584
Abstract

Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical measurements of the conformational transitions in grafted polymer chains and polymer brushes. Primary attention is paid to the grafting density and the length and spatial arrangement of grafted chains, the role of polystyrene, organosilane or alkanethiol sublayers and their effects on adsorption of proteins and adhesion of cells. The key... (More)

Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical measurements of the conformational transitions in grafted polymer chains and polymer brushes. Primary attention is paid to the grafting density and the length and spatial arrangement of grafted chains, the role of polystyrene, organosilane or alkanethiol sublayers and their effects on adsorption of proteins and adhesion of cells. The key applications of grafted smart polymers such as cell culture and tissue engineering, cell and protein separation, biosensing and targeted drug delivery are surveyed. The bibliography includes 174 references.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Russian Chemical Reviews
volume
85
issue
6
pages
20 pages
publisher
Turpion Ltd.
external identifiers
  • scopus:84978538415
  • wos:000379356100002
ISSN
0036-021X
DOI
10.1070/RCR4567
language
English
LU publication?
yes
id
f4eb51e2-15ad-4799-a562-c2ab0b18c069
date added to LUP
2017-02-07 12:16:34
date last changed
2017-09-18 11:37:21
@article{f4eb51e2-15ad-4799-a562-c2ab0b18c069,
  abstract     = {<p>Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical measurements of the conformational transitions in grafted polymer chains and polymer brushes. Primary attention is paid to the grafting density and the length and spatial arrangement of grafted chains, the role of polystyrene, organosilane or alkanethiol sublayers and their effects on adsorption of proteins and adhesion of cells. The key applications of grafted smart polymers such as cell culture and tissue engineering, cell and protein separation, biosensing and targeted drug delivery are surveyed. The bibliography includes 174 references.</p>},
  author       = {Ivanov, Alexander E. and Zubov, Vitaly P.},
  issn         = {0036-021X},
  language     = {eng},
  number       = {6},
  pages        = {565--584},
  publisher    = {Turpion Ltd.},
  series       = {Russian Chemical Reviews},
  title        = {Smart polymers as surface modifiers for bioanalytical devices and biomaterials : Theory and practice},
  url          = {http://dx.doi.org/10.1070/RCR4567},
  volume       = {85},
  year         = {2016},
}