Consensus Recommendations on Pathologic Changes in the Hippocampus: A Postmortem Multicenter Inter-Rater Study.
(2013) In Journal of Neuropathology and Experimental Neurology 72(6). p.452-461- Abstract
- There is no consensus on the pathologic conditions or severity implied by the term "hippocampal sclerosis" (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term "HS." In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular... (More)
- There is no consensus on the pathologic conditions or severity implied by the term "hippocampal sclerosis" (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term "HS." In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the term "HS" should be applied to all cases with complete/near-complete neuronal loss and gliosis in the subfields of the cornu Ammonis but not to hippocampal microinfarction. Therefore, the etiology of HS must be defined in association with a neurodegenerative process or as "lacking neurodegenerative markers," a pathologic condition presumed to arise from hypoxic/ischemic mechanisms. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3804750
- author
- Rauramaa, Tuomas ; Pikkarainen, Maria ; Englund, Elisabet LU ; Ince, Paul G ; Jellinger, Kurt ; Paetau, Anders and Alafuzoff, Irina
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuropathology and Experimental Neurology
- volume
- 72
- issue
- 6
- pages
- 452 - 461
- publisher
- American Association of Neuropathologists
- external identifiers
-
- wos:000319454400001
- pmid:23656988
- scopus:84878628255
- pmid:23656988
- ISSN
- 1554-6578
- DOI
- 10.1097/NEN.0b013e318292492a
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- f5097c77-fb96-4e35-bb78-cfc6190b6622 (old id 3804750)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23656988?dopt=Abstract
- date added to LUP
- 2016-04-01 10:57:33
- date last changed
- 2022-04-20 07:49:04
@article{f5097c77-fb96-4e35-bb78-cfc6190b6622, abstract = {{There is no consensus on the pathologic conditions or severity implied by the term "hippocampal sclerosis" (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term "HS." In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the term "HS" should be applied to all cases with complete/near-complete neuronal loss and gliosis in the subfields of the cornu Ammonis but not to hippocampal microinfarction. Therefore, the etiology of HS must be defined in association with a neurodegenerative process or as "lacking neurodegenerative markers," a pathologic condition presumed to arise from hypoxic/ischemic mechanisms.}}, author = {{Rauramaa, Tuomas and Pikkarainen, Maria and Englund, Elisabet and Ince, Paul G and Jellinger, Kurt and Paetau, Anders and Alafuzoff, Irina}}, issn = {{1554-6578}}, language = {{eng}}, number = {{6}}, pages = {{452--461}}, publisher = {{American Association of Neuropathologists}}, series = {{Journal of Neuropathology and Experimental Neurology}}, title = {{Consensus Recommendations on Pathologic Changes in the Hippocampus: A Postmortem Multicenter Inter-Rater Study.}}, url = {{http://dx.doi.org/10.1097/NEN.0b013e318292492a}}, doi = {{10.1097/NEN.0b013e318292492a}}, volume = {{72}}, year = {{2013}}, }