Effectiveness of traditional chinese exercise for symptoms of knee osteoarthritis : A systematic review and meta-analysis of randomized controlled trials
Li, Ruojin ; Chen, Hongwei ; Feng, Jiahao ; Xiao, Ying ; Zhang, Haoyang LU
; Lam, Christopher Wai Kei
and Xiao, Hong
(2020)
In International Journal of Environmental Research and Public Health
17(21).
p.1-18
- Abstract
Background: Growing evidences have advocated the potential benefits of traditional Chinese exercise (TCE) on symptomatic improvement of knee osteoarthritis (KOA). However, most of them have been derived from cross-sectional studies or case reports; the effectiveness of TCE therapies has not been fully assessed with a randomized control trial (RCT). In order to evaluate the combined clinical effectiveness of TCE for KOA, we conducted a systematic review and meta-analysis on the existing RCTs on KOA. Methods: A systematic search was performed in four electronic databases: PubMed, Web of Science, Cochrane Library, and EMBASE from the time of their inception to February 2020. All eligible RCTs were included in which TCE was utilized for... (More)
Background: Growing evidences have advocated the potential benefits of traditional Chinese exercise (TCE) on symptomatic improvement of knee osteoarthritis (KOA). However, most of them have been derived from cross-sectional studies or case reports; the effectiveness of TCE therapies has not been fully assessed with a randomized control trial (RCT). In order to evaluate the combined clinical effectiveness of TCE for KOA, we conducted a systematic review and meta-analysis on the existing RCTs on KOA. Methods: A systematic search was performed in four electronic databases: PubMed, Web of Science, Cochrane Library, and EMBASE from the time of their inception to February 2020. All eligible RCTs were included in which TCE was utilized for treating KOA as compared to a control group. Two reviewers independently extracted the data and evaluated the risk of bias following the Cochrane Risk of Bias Tool for RCT. The symptoms of KOA evaluated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) were regarded as the primary outcomes in this study. Each outcome measure was pooled by a standardized mean difference (SMD) with 95% confidence intervals (CI). A meta-analysis was applied with a random or fixed effect model for the collected data to calculate the summary SMD with 95% CI based on different statistical heterogeneity. In addition, subgroup analyses were used to investigate heterogeneity and sensitivity analysis was carried out for the results of the meta-analysis. Egger’s test and the funnel plots were used to examine the potential bias in the RCTs. Results: A total of 14 RCTs involving 815 patients with KOA were included. Compared with a control group; the synthesized data of TCE showed a significant improvement in WOMAC/KOOS pain score (SMD = −0.61; 95% CI: −0.86 to −0.37; p < 0.001), stiffness score (SMD = −0.75; 95% CI: −1.09 to −0.41; p < 0.001), and physical function score (SMD = −0.67; 95% CI: −0.82 to −0.53; p < 0.001). Conclusions: Our meta-analysis suggested that TCE may be effective in alleviating pain; relieving stiffness and improving the physical function for patients with KOA. Yet; given the methodological limitations of included RCTs in this meta-analysis; more high-quality RCTs with large sample size and long-term intervention are required to further confirm the effectiveness and underlying mechanisms of TCE for treating KOA.
(Less)
- author
- Li, Ruojin
; Chen, Hongwei
; Feng, Jiahao
; Xiao, Ying
; Zhang, Haoyang
LU
; Lam, Christopher Wai Kei
and Xiao, Hong
- publishing date
- 2020-11-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Baduanjin, Knee osteoarthritis (KOA), Meta-analysis, Systematic review, Tai chi, Traditional chinese exercise
- in
- International Journal of Environmental Research and Public Health
- volume
- 17
- issue
- 21
- article number
- 7873
- pages
- 1 - 18
- publisher
- MDPI AG
- external identifiers
-
- scopus:85094179799
- pmid:33121082
- ISSN
- 1661-7827
- DOI
- 10.3390/ijerph17217873
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- id
- f50d675e-a552-4b3c-a749-dde5112f6c80
- date added to LUP
- 2024-02-05 15:53:50
- date last changed
- 2024-07-30 08:42:57
@article{f50d675e-a552-4b3c-a749-dde5112f6c80,
abstract = {{<p>Background: Growing evidences have advocated the potential benefits of traditional Chinese exercise (TCE) on symptomatic improvement of knee osteoarthritis (KOA). However, most of them have been derived from cross-sectional studies or case reports; the effectiveness of TCE therapies has not been fully assessed with a randomized control trial (RCT). In order to evaluate the combined clinical effectiveness of TCE for KOA, we conducted a systematic review and meta-analysis on the existing RCTs on KOA. Methods: A systematic search was performed in four electronic databases: PubMed, Web of Science, Cochrane Library, and EMBASE from the time of their inception to February 2020. All eligible RCTs were included in which TCE was utilized for treating KOA as compared to a control group. Two reviewers independently extracted the data and evaluated the risk of bias following the Cochrane Risk of Bias Tool for RCT. The symptoms of KOA evaluated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) were regarded as the primary outcomes in this study. Each outcome measure was pooled by a standardized mean difference (SMD) with 95% confidence intervals (CI). A meta-analysis was applied with a random or fixed effect model for the collected data to calculate the summary SMD with 95% CI based on different statistical heterogeneity. In addition, subgroup analyses were used to investigate heterogeneity and sensitivity analysis was carried out for the results of the meta-analysis. Egger’s test and the funnel plots were used to examine the potential bias in the RCTs. Results: A total of 14 RCTs involving 815 patients with KOA were included. Compared with a control group; the synthesized data of TCE showed a significant improvement in WOMAC/KOOS pain score (SMD = −0.61; 95% CI: −0.86 to −0.37; p < 0.001), stiffness score (SMD = −0.75; 95% CI: −1.09 to −0.41; p < 0.001), and physical function score (SMD = −0.67; 95% CI: −0.82 to −0.53; p < 0.001). Conclusions: Our meta-analysis suggested that TCE may be effective in alleviating pain; relieving stiffness and improving the physical function for patients with KOA. Yet; given the methodological limitations of included RCTs in this meta-analysis; more high-quality RCTs with large sample size and long-term intervention are required to further confirm the effectiveness and underlying mechanisms of TCE for treating KOA.</p>}},
author = {{Li, Ruojin and Chen, Hongwei and Feng, Jiahao and Xiao, Ying and Zhang, Haoyang and Lam, Christopher Wai Kei and Xiao, Hong}},
issn = {{1661-7827}},
keywords = {{Baduanjin; Knee osteoarthritis (KOA); Meta-analysis; Systematic review; Tai chi; Traditional chinese exercise}},
language = {{eng}},
month = {{11}},
number = {{21}},
pages = {{1--18}},
publisher = {{MDPI AG}},
series = {{International Journal of Environmental Research and Public Health}},
title = {{Effectiveness of traditional chinese exercise for symptoms of knee osteoarthritis : A systematic review and meta-analysis of randomized controlled trials}},
url = {{http://dx.doi.org/10.3390/ijerph17217873}},
doi = {{10.3390/ijerph17217873}},
volume = {{17}},
year = {{2020}},
}