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Microbeam radiation therapy - Grid therapy and beyond : A clinical perspective

Schültke, Elisabeth; Balosso, Jacques; Breslin, Thomas LU ; Cavaletti, Guido; Djonov, Valentin; Esteve, Francois; Grotzer, Michael; Hildebrandt, Guido; Valdman, Alexander and Laissue, Jean (2017) In British Journal of Radiology 90(1078).
Abstract

Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Radiology
volume
90
issue
1078
publisher
British Inst Radiology
external identifiers
  • scopus:85030770188
  • wos:000411905800008
ISSN
0007-1285
DOI
10.1259/bjr.20170073
language
English
LU publication?
yes
id
f5198177-910d-4a7a-b4cf-77a160f98ead
date added to LUP
2017-11-06 16:46:38
date last changed
2018-05-20 04:38:34
@article{f5198177-910d-4a7a-b4cf-77a160f98ead,
  abstract     = {<p>Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.</p>},
  articleno    = {20170073},
  author       = {Schültke, Elisabeth and Balosso, Jacques and Breslin, Thomas and Cavaletti, Guido and Djonov, Valentin and Esteve, Francois and Grotzer, Michael and Hildebrandt, Guido and Valdman, Alexander and Laissue, Jean},
  issn         = {0007-1285},
  language     = {eng},
  number       = {1078},
  publisher    = {British Inst Radiology},
  series       = {British Journal of Radiology},
  title        = {Microbeam radiation therapy - Grid therapy and beyond : A clinical perspective},
  url          = {http://dx.doi.org/10.1259/bjr.20170073},
  volume       = {90},
  year         = {2017},
}