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INCREASED LEVELS OF ADVANCED GLYCATION END PRODUCTS ARE ASSOCIATED WITH HIGHER AORTIC STIFFNESS IN YOUNGER INDIVIDUALS OF THE GENERAL POPULATION

Johansson, Madeleine LU orcid ; Jujic, Amra ; Engström, Gunnar LU and Nilsson, Peter M LU (2023) Eruopean Society of Hypertension 2023 Annual Meeting In Journal of Hypertension 41(Suppl 3). p.269-269
Abstract
Objective:
Advanced Glycation End products (AGEs) is an established risk marker in diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in older individuals. The relationship between aortic stiffness and AGEs has not been thoroughly examined in the younger population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and mid-aged adults with few comorbidities.

Design and method:
We cross-sectionally analysed 2518 participants from a prospective population-based cohort (mean age 41.8±14.5 years, 52.2% women). Advanced glycation end-products were measured as skin autofluorescence with AGE-Reader™,... (More)
Objective:
Advanced Glycation End products (AGEs) is an established risk marker in diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in older individuals. The relationship between aortic stiffness and AGEs has not been thoroughly examined in the younger population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and mid-aged adults with few comorbidities.

Design and method:
We cross-sectionally analysed 2518 participants from a prospective population-based cohort (mean age 41.8±14.5 years, 52.2% women). Advanced glycation end-products were measured as skin autofluorescence with AGE-Reader™, which is a well-validated, non-invasive method. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cf-PWV) and augmentation index adjusted for resting heart rate (Aix) at the arteria radialis using SphygmoCor®. Linear regression stratified by age equal to or below 50 years (n = 1689) and 51 years and above (n = 829) was used to analyse associations between AGEs, and PWV and Aix in a univariate model and multivariable model adjusted for sex, body mass index, systolic blood pressure, heart rate, fasting glucose, estimated glomerular filtration rate, low-density-lipoprotein, and current smoking.

Results:
Mean cf-PWV and Aix across quartiles of AGEs in both age groups are shown in Figure 1. We found that one unit increase in skin autofluorescence was significantly associated with direct aortic stiffness (cf-PWV) after adjustment in younger individuals below or equal to 50 years old (unstandardized beta-coefficient (B) cf-PWV 0.59 m/s, p
Conclusions:
Our findings show that higher levels of advanced glycation end products are positively associated with increased direct and indirect arterial stiffness in younger individuals with few comorbidities, independent of cardiometabolic risk factors. Future studies are warranted to elucidate the effect of reduced AGE dietary consumption and AGE-inhibition on aortic stiffness. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aortic stiffness, glucose, population study, arterial stiffness
in
Journal of Hypertension
volume
41
issue
Suppl 3
pages
269 - 269
publisher
Lippincott Williams & Wilkins
conference name
Eruopean Society of Hypertension 2023 Annual Meeting
conference location
Milan, Italy
conference dates
2023-06-23 - 2023-06-26
ISSN
1473-5598
DOI
10.1097/01.hjh.0000941784.85947.c4
language
English
LU publication?
yes
id
f51f421f-d1ad-4d2c-ae80-549de31b4e22
date added to LUP
2023-06-28 14:10:57
date last changed
2023-07-14 07:59:57
@misc{f51f421f-d1ad-4d2c-ae80-549de31b4e22,
  abstract     = {{Objective: <br/>Advanced Glycation End products (AGEs) is an established risk marker in diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in older individuals. The relationship between aortic stiffness and AGEs has not been thoroughly examined in the younger population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and mid-aged adults with few comorbidities.<br/><br/>Design and method: <br/>We cross-sectionally analysed 2518 participants from a prospective population-based cohort (mean age 41.8±14.5 years, 52.2% women). Advanced glycation end-products were measured as skin autofluorescence with AGE-Reader™, which is a well-validated, non-invasive method. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cf-PWV) and augmentation index adjusted for resting heart rate (Aix) at the arteria radialis using SphygmoCor®. Linear regression stratified by age equal to or below 50 years (n = 1689) and 51 years and above (n = 829) was used to analyse associations between AGEs, and PWV and Aix in a univariate model and multivariable model adjusted for sex, body mass index, systolic blood pressure, heart rate, fasting glucose, estimated glomerular filtration rate, low-density-lipoprotein, and current smoking.<br/><br/>Results: <br/>Mean cf-PWV and Aix across quartiles of AGEs in both age groups are shown in Figure 1. We found that one unit increase in skin autofluorescence was significantly associated with direct aortic stiffness (cf-PWV) after adjustment in younger individuals below or equal to 50 years old (unstandardized beta-coefficient (B) cf-PWV 0.59 m/s, p<br/>Conclusions: <br/>Our findings show that higher levels of advanced glycation end products are positively associated with increased direct and indirect arterial stiffness in younger individuals with few comorbidities, independent of cardiometabolic risk factors. Future studies are warranted to elucidate the effect of reduced AGE dietary consumption and AGE-inhibition on aortic stiffness.}},
  author       = {{Johansson, Madeleine and Jujic, Amra and Engström, Gunnar and Nilsson, Peter M}},
  issn         = {{1473-5598}},
  keywords     = {{Aortic stiffness; glucose; population study; arterial stiffness}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{Suppl 3}},
  pages        = {{269--269}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Hypertension}},
  title        = {{INCREASED LEVELS OF ADVANCED GLYCATION END PRODUCTS ARE ASSOCIATED WITH HIGHER AORTIC STIFFNESS IN YOUNGER INDIVIDUALS OF THE GENERAL POPULATION}},
  url          = {{http://dx.doi.org/10.1097/01.hjh.0000941784.85947.c4}},
  doi          = {{10.1097/01.hjh.0000941784.85947.c4}},
  volume       = {{41}},
  year         = {{2023}},
}