Early and supernormal vascular aging : Clinical characteristics and association with incident cardiovascular events
(2020) In Hypertension p.1616-1624- Abstract
Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define... (More)
Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define early (Δ-age<-5.7 years), normal (Δ-age -5.7 to 6.8 years) and supernormal vascular aging (Δ-age>6.8 years). The risk for fatal and nonfatal cardiovascular events associated with vascular aging categories was investigated in the Malmö Diet and Cancer Study cohort (n=2642). In the Malmö Diet and Cancer Study Cohort (6.6-year follow-up, 286 events), Δ-age was significantly (P<0.01) and inversely associated with cardiovascular events. Compared with normal vascular aging, supernormal vascular aging had lower risk (hazard ratio, 0.59 [95% CI, 0.41-0.85]), whereas early vascular aging had higher risk (hazard ratio, 2.70 [95% CI, 1.55-4.70]) of cardiovascular events, in particular coronary events. There was no significant association with all-cause mortality. This study represents the first validation of the clinical significance of the supernormal vascular aging concept, based on prospective data. Its further characterization may help discovering novel protective molecular pathways and providing preventive strategies for successful vascular aging.
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- author
- Bruno, Rosa Maria ; Nilsson, Peter M. LU ; Engström, Gunnar LU ; Wadström, Benjamin Nilsson ; Empana, Jean Philippe ; Boutouyrie, Pierre and Laurent, Stephane
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aging, Blood pressure, Mortality, Risk factors, Vascular stiffness
- in
- Hypertension
- pages
- 9 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85092749892
- pmid:32895017
- ISSN
- 0194-911X
- DOI
- 10.1161/HYPERTENSIONAHA.120.14971
- language
- English
- LU publication?
- yes
- id
- f55663a2-cd37-47e0-9d01-15ba5c5850ef
- date added to LUP
- 2020-11-11 11:15:59
- date last changed
- 2024-04-17 18:29:50
@article{f55663a2-cd37-47e0-9d01-15ba5c5850ef,
abstract = {{<p>Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define early (Δ-age<-5.7 years), normal (Δ-age -5.7 to 6.8 years) and supernormal vascular aging (Δ-age>6.8 years). The risk for fatal and nonfatal cardiovascular events associated with vascular aging categories was investigated in the Malmö Diet and Cancer Study cohort (n=2642). In the Malmö Diet and Cancer Study Cohort (6.6-year follow-up, 286 events), Δ-age was significantly (P<0.01) and inversely associated with cardiovascular events. Compared with normal vascular aging, supernormal vascular aging had lower risk (hazard ratio, 0.59 [95% CI, 0.41-0.85]), whereas early vascular aging had higher risk (hazard ratio, 2.70 [95% CI, 1.55-4.70]) of cardiovascular events, in particular coronary events. There was no significant association with all-cause mortality. This study represents the first validation of the clinical significance of the supernormal vascular aging concept, based on prospective data. Its further characterization may help discovering novel protective molecular pathways and providing preventive strategies for successful vascular aging.</p>}},
author = {{Bruno, Rosa Maria and Nilsson, Peter M. and Engström, Gunnar and Wadström, Benjamin Nilsson and Empana, Jean Philippe and Boutouyrie, Pierre and Laurent, Stephane}},
issn = {{0194-911X}},
keywords = {{Aging; Blood pressure; Mortality; Risk factors; Vascular stiffness}},
language = {{eng}},
pages = {{1616--1624}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Hypertension}},
title = {{Early and supernormal vascular aging : Clinical characteristics and association with incident cardiovascular events}},
url = {{http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14971}},
doi = {{10.1161/HYPERTENSIONAHA.120.14971}},
year = {{2020}},
}