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Impact of Underweight, Overweight, and Obesity on Health-Related Quality of Life in Children with Tetralogy of Fallot Variants

Hidestrand, Pip ; Svensson, Birgitta LU ; Simpson, Pippa ; Liuba, Petru LU and Weismann, Constance G. LU orcid (2024) In Pediatric Cardiology
Abstract

Traditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for cardiovascular morbidity and mortality. The aim of this study was to evaluate whether body mass index (BMI) is associated with health-related quality of life (HRQoL) in patients with variants of Tetralogy of Fallot (TOF). Patients and parents of children with variants of TOF–CHD were asked to fill out the PedsQL 4.0 questionnaire and provide weight and length. Patients were categorized into low, normal, and high BMI percentiles. Other demographic data were obtained from the Swedish national registry for congenital heart disease (SWEDCON). Statistical analyses included non-parametric Mann–Whitney U test, Fisher exact, and... (More)

Traditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for cardiovascular morbidity and mortality. The aim of this study was to evaluate whether body mass index (BMI) is associated with health-related quality of life (HRQoL) in patients with variants of Tetralogy of Fallot (TOF). Patients and parents of children with variants of TOF–CHD were asked to fill out the PedsQL 4.0 questionnaire and provide weight and length. Patients were categorized into low, normal, and high BMI percentiles. Other demographic data were obtained from the Swedish national registry for congenital heart disease (SWEDCON). Statistical analyses included non-parametric Mann–Whitney U test, Fisher exact, and Chi-square tests. Eighty-five patients were included. Twelve were overweight or obese, 57 had a normal BMI, and 16 were underweight. There was a significant difference in age and gender between the groups. Comparing overweight/obese children to those with normal BMI, physical and social functioning were impaired, while emotional and school function were comparable between the groups. This applied to both child and parental assessment. When comparing underweight to normal weight children, school functioning assessed by the parent was the only domain significantly different from patients with a normal BMI. Children with variants of TOF and overweight/obesity have lower HRQoL, particularly in physical and social functioning, while underweight children may have impaired school functioning. We suggest that preventive measures aimed at maintaining a normal weight should be taken early in life to reduce long-term cardiovascular risk in the CHD population.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Body mass index, Congenital heart disease, Health-related quality of life, Obesity, Overweight, Right ventricular outflow tract, Tetralogy of Fallot
in
Pediatric Cardiology
publisher
Springer
external identifiers
  • pmid:38506963
  • scopus:85188189151
ISSN
0172-0643
DOI
10.1007/s00246-024-03416-w
language
English
LU publication?
yes
id
f59ab308-43b5-496b-b7d3-9d074f3b3512
date added to LUP
2024-04-04 15:44:57
date last changed
2024-04-18 18:00:55
@article{f59ab308-43b5-496b-b7d3-9d074f3b3512,
  abstract     = {{<p>Traditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for cardiovascular morbidity and mortality. The aim of this study was to evaluate whether body mass index (BMI) is associated with health-related quality of life (HRQoL) in patients with variants of Tetralogy of Fallot (TOF). Patients and parents of children with variants of TOF–CHD were asked to fill out the PedsQL 4.0 questionnaire and provide weight and length. Patients were categorized into low, normal, and high BMI percentiles. Other demographic data were obtained from the Swedish national registry for congenital heart disease (SWEDCON). Statistical analyses included non-parametric Mann–Whitney U test, Fisher exact, and Chi-square tests. Eighty-five patients were included. Twelve were overweight or obese, 57 had a normal BMI, and 16 were underweight. There was a significant difference in age and gender between the groups. Comparing overweight/obese children to those with normal BMI, physical and social functioning were impaired, while emotional and school function were comparable between the groups. This applied to both child and parental assessment. When comparing underweight to normal weight children, school functioning assessed by the parent was the only domain significantly different from patients with a normal BMI. Children with variants of TOF and overweight/obesity have lower HRQoL, particularly in physical and social functioning, while underweight children may have impaired school functioning. We suggest that preventive measures aimed at maintaining a normal weight should be taken early in life to reduce long-term cardiovascular risk in the CHD population.</p>}},
  author       = {{Hidestrand, Pip and Svensson, Birgitta and Simpson, Pippa and Liuba, Petru and Weismann, Constance G.}},
  issn         = {{0172-0643}},
  keywords     = {{Body mass index; Congenital heart disease; Health-related quality of life; Obesity; Overweight; Right ventricular outflow tract; Tetralogy of Fallot}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Pediatric Cardiology}},
  title        = {{Impact of Underweight, Overweight, and Obesity on Health-Related Quality of Life in Children with Tetralogy of Fallot Variants}},
  url          = {{http://dx.doi.org/10.1007/s00246-024-03416-w}},
  doi          = {{10.1007/s00246-024-03416-w}},
  year         = {{2024}},
}