The protective role of ROS in autoimmune disease.
(2009) In Trends in Immunology 30. p.201-208- Abstract
- For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) complex have been considered harmful mediators of inflammation owing to their highly reactive nature. However, there are an increasing number of findings suggesting that ROS produced by the NOX2 complex are anti-inflammatory and prevent autoimmune responses, thus challenging existing dogma. ROS might not only be produced as a mechanism to eradicate invading pathogens, but rather as a means by which to fine-tune the inflammatory response, depending on when, where and at what amounts they are produced. In this review, we aim to describe the current findings highlighting ROS as regulators of autoimmune inflammation, focusing on autoimmune arthritis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1392249
- author
- Hultqvist, Malin LU ; Olsson, Lina LU ; Gelderman, Kyra LU and Holmdahl, Rikard LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Immunology
- volume
- 30
- pages
- 201 - 208
- publisher
- Elsevier
- external identifiers
-
- wos:000266431800003
- pmid:19356981
- scopus:65449170860
- pmid:19356981
- ISSN
- 1471-4981
- DOI
- 10.1016/j.it.2009.03.004
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- f5dba947-79cc-447f-bd1d-9ae58192b7be (old id 1392249)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19356981?dopt=Abstract
- date added to LUP
- 2016-04-04 07:38:31
- date last changed
- 2022-02-05 22:50:15
@article{f5dba947-79cc-447f-bd1d-9ae58192b7be, abstract = {{For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) complex have been considered harmful mediators of inflammation owing to their highly reactive nature. However, there are an increasing number of findings suggesting that ROS produced by the NOX2 complex are anti-inflammatory and prevent autoimmune responses, thus challenging existing dogma. ROS might not only be produced as a mechanism to eradicate invading pathogens, but rather as a means by which to fine-tune the inflammatory response, depending on when, where and at what amounts they are produced. In this review, we aim to describe the current findings highlighting ROS as regulators of autoimmune inflammation, focusing on autoimmune arthritis.}}, author = {{Hultqvist, Malin and Olsson, Lina and Gelderman, Kyra and Holmdahl, Rikard}}, issn = {{1471-4981}}, language = {{eng}}, pages = {{201--208}}, publisher = {{Elsevier}}, series = {{Trends in Immunology}}, title = {{The protective role of ROS in autoimmune disease.}}, url = {{http://dx.doi.org/10.1016/j.it.2009.03.004}}, doi = {{10.1016/j.it.2009.03.004}}, volume = {{30}}, year = {{2009}}, }