X-linked Alport syndrome: Natural history and genotype-phenotype correlations in girls and women belonging to 195 families: A "European community Alport syndrome concerted action" study
(2003) In Journal of the American Society of Nephrology 14(10). p.2603-2610- Abstract
- Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disease in girls and women. A "European Community Alport Syndrome Concerted Action" (ECASCA) group was established to delineate the Alport syndrome phenotype in each gender and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X-linked transmission, were collected. Characteristics of heterozygous girls and women belonging to the 195 families with proven COL4A5 mutation are... (More)
- Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disease in girls and women. A "European Community Alport Syndrome Concerted Action" (ECASCA) group was established to delineate the Alport syndrome phenotype in each gender and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X-linked transmission, were collected. Characteristics of heterozygous girls and women belonging to the 195 families with proven COL4A5 mutation are compared with those of hemizygous boys and men. Hematuria was observed in 95% of carriers and consistently absent in the others. Proteinuria, hearing loss, and ocular defects developed in 75%, 28%, and 15%, respectively. The probability of developing end-stage renal disease or deafness before the age of 40 yr was 12% and 10%, respectively, in girls and women versus 90 and 80%, respectively, in boys and men. The risk of progression to end-stage renal disease appears to increase after the age of 60 yr in women. Because of the absence of genotype-phenotype correlation and the large intrafamilial phenotypic heterogeneity, early prognosis of the disease in X-linked Alport syndrome carriers remains moot. Risk factors for developing renal failure have been identified: the occurrence and progressive increase in proteinuria, and the development of a hearing defect. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/300069
- author
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the American Society of Nephrology
- volume
- 14
- issue
- 10
- pages
- 2603 - 2610
- publisher
- American Society of Nephrology
- external identifiers
-
- pmid:14514738
- wos:000185540800022
- scopus:0141566829
- ISSN
- 1046-6673
- DOI
- 10.1097/01.ASN.0000090034.71205.74
- language
- English
- LU publication?
- yes
- id
- f5e24a70-45a2-46b0-96f3-327325e2e018 (old id 300069)
- alternative location
- http://jasn.asnjournals.org/cgi/content/abstract/14/10/2603
- date added to LUP
- 2016-04-01 16:13:48
- date last changed
- 2022-03-30 06:21:14
@article{f5e24a70-45a2-46b0-96f3-327325e2e018,
abstract = {{Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disease in girls and women. A "European Community Alport Syndrome Concerted Action" (ECASCA) group was established to delineate the Alport syndrome phenotype in each gender and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X-linked transmission, were collected. Characteristics of heterozygous girls and women belonging to the 195 families with proven COL4A5 mutation are compared with those of hemizygous boys and men. Hematuria was observed in 95% of carriers and consistently absent in the others. Proteinuria, hearing loss, and ocular defects developed in 75%, 28%, and 15%, respectively. The probability of developing end-stage renal disease or deafness before the age of 40 yr was 12% and 10%, respectively, in girls and women versus 90 and 80%, respectively, in boys and men. The risk of progression to end-stage renal disease appears to increase after the age of 60 yr in women. Because of the absence of genotype-phenotype correlation and the large intrafamilial phenotypic heterogeneity, early prognosis of the disease in X-linked Alport syndrome carriers remains moot. Risk factors for developing renal failure have been identified: the occurrence and progressive increase in proteinuria, and the development of a hearing defect.}},
author = {{Jais, JP and Knebelmann, B and Giatras, I and De Marchi, M and Rizzoni, G and Renieri, A and Weber, M and Gross, O and Netzer, KO and Flinter, F and Pirson, Y and Dahan, K and Wieslander, Jörgen and Persson, Ulf and Tryggvason, K and Martin, P and Hertz, JM and Schroder, C and Sanak, M and Carvalho, MF and Saus, J and Antignac, C and Smeets, H and Gubler, MC}},
issn = {{1046-6673}},
language = {{eng}},
number = {{10}},
pages = {{2603--2610}},
publisher = {{American Society of Nephrology}},
series = {{Journal of the American Society of Nephrology}},
title = {{X-linked Alport syndrome: Natural history and genotype-phenotype correlations in girls and women belonging to 195 families: A "European community Alport syndrome concerted action" study}},
url = {{http://dx.doi.org/10.1097/01.ASN.0000090034.71205.74}},
doi = {{10.1097/01.ASN.0000090034.71205.74}},
volume = {{14}},
year = {{2003}},
}