Subtle Differences in Brain Architecture in Patients with Congenital Anosmia
(2022) In Brain Topography 35(3). p.337-340- Abstract
People suffering from congenital anosmia show normal brain architecture although they do not have functional sense of smell. Some studies in this regard point to the changes in secondary olfactory cortex, orbitofrontal cortex (OFC), in terms of gray matter volume increase. However, diffusion tensor imaging has not been explored so far. We included 13 congenital anosmia subjects together with 15 controls and looked into various diffusion parameters like FA. Increased FA in bilateral OFC confirms the earlier studies reporting increased gray matter thickness. However, it is quite difficult to interpret FA in terms of gray matter volume. Increased FA has been seen with recovery after traumatic brain injury. Such changes in OFC point to the... (More)
People suffering from congenital anosmia show normal brain architecture although they do not have functional sense of smell. Some studies in this regard point to the changes in secondary olfactory cortex, orbitofrontal cortex (OFC), in terms of gray matter volume increase. However, diffusion tensor imaging has not been explored so far. We included 13 congenital anosmia subjects together with 15 controls and looked into various diffusion parameters like FA. Increased FA in bilateral OFC confirms the earlier studies reporting increased gray matter thickness. However, it is quite difficult to interpret FA in terms of gray matter volume. Increased FA has been seen with recovery after traumatic brain injury. Such changes in OFC point to the plastic nature of the brain.
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- author
- Thaploo, Divesh ; Georgiopoulos, Charalampos LU ; Haehner, Antje and Hummel, Thomas
- publishing date
- 2022-05
- type
- Contribution to journal
- publication status
- published
- keywords
- Brain/diagnostic imaging, Diffusion Tensor Imaging, Gray Matter/diagnostic imaging, Humans, Magnetic Resonance Imaging, Olfaction Disorders/congenital
- in
- Brain Topography
- volume
- 35
- issue
- 3
- pages
- 337 - 340
- publisher
- Springer
- external identifiers
-
- scopus:85127491620
- pmid:35325351
- ISSN
- 0896-0267
- DOI
- 10.1007/s10548-022-00895-z
- language
- English
- LU publication?
- no
- additional info
- © 2022. The Author(s).
- id
- f5eb6601-aa0a-4eff-8273-c7ca1bb00b8c
- date added to LUP
- 2023-02-09 11:16:35
- date last changed
- 2024-04-17 11:57:00
@article{f5eb6601-aa0a-4eff-8273-c7ca1bb00b8c,
abstract = {{<p>People suffering from congenital anosmia show normal brain architecture although they do not have functional sense of smell. Some studies in this regard point to the changes in secondary olfactory cortex, orbitofrontal cortex (OFC), in terms of gray matter volume increase. However, diffusion tensor imaging has not been explored so far. We included 13 congenital anosmia subjects together with 15 controls and looked into various diffusion parameters like FA. Increased FA in bilateral OFC confirms the earlier studies reporting increased gray matter thickness. However, it is quite difficult to interpret FA in terms of gray matter volume. Increased FA has been seen with recovery after traumatic brain injury. Such changes in OFC point to the plastic nature of the brain.</p>}},
author = {{Thaploo, Divesh and Georgiopoulos, Charalampos and Haehner, Antje and Hummel, Thomas}},
issn = {{0896-0267}},
keywords = {{Brain/diagnostic imaging; Diffusion Tensor Imaging; Gray Matter/diagnostic imaging; Humans; Magnetic Resonance Imaging; Olfaction Disorders/congenital}},
language = {{eng}},
number = {{3}},
pages = {{337--340}},
publisher = {{Springer}},
series = {{Brain Topography}},
title = {{Subtle Differences in Brain Architecture in Patients with Congenital Anosmia}},
url = {{http://dx.doi.org/10.1007/s10548-022-00895-z}},
doi = {{10.1007/s10548-022-00895-z}},
volume = {{35}},
year = {{2022}},
}