An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione
(1993) In Synthetic Communications 23(11). p.1499-1505- Abstract
- Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (IR, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/31490
- author
- Almqvist, Fredrik ; Eklund, Lars and Frejd, Torbjörn LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Synthetic Communications
- volume
- 23
- issue
- 11
- pages
- 1499 - 1505
- publisher
- Marcel Dekker
- external identifiers
-
- scopus:0027319329
- ISSN
- 0039-7911
- DOI
- 10.1080/00397919308011243
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- f6232f39-ddb5-432a-b667-e12c4420bc7a (old id 31490)
- date added to LUP
- 2016-04-01 16:50:37
- date last changed
- 2021-01-03 06:52:06
@article{f6232f39-ddb5-432a-b667-e12c4420bc7a, abstract = {{Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (IR, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.}}, author = {{Almqvist, Fredrik and Eklund, Lars and Frejd, Torbjörn}}, issn = {{0039-7911}}, language = {{eng}}, number = {{11}}, pages = {{1499--1505}}, publisher = {{Marcel Dekker}}, series = {{Synthetic Communications}}, title = {{An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione}}, url = {{http://dx.doi.org/10.1080/00397919308011243}}, doi = {{10.1080/00397919308011243}}, volume = {{23}}, year = {{1993}}, }