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Extending the modified Bayesian Information Criterion (mBIC) to dense markers and multiple interval mapping

Bogdan, Malgorzata LU ; Frommlet, Florian ; Biecek, Przemysław ; Cheng, Riyan ; Ghosh, Jayanta K. and Doerge, R. W. (2008) In Biometrics 64(4). p.1162-1169
Abstract

The modified version of Bayesian Information Criterion (mBIC) is a relatively simple model selection procedure that can be used when locating multiple interacting quantitative trait loci (QTL). Our earlier work demonstrated the statistical properties of mBIC for situations where the average genetic map interval is at least 5 cM. In this work mBIC is adapted to genome searches based on a dense map and, more importantly, to the situation where consecutive QTL and interactions are located by multiple interval mapping. Easy to use formulas for the extended mBIC are given. A simulation study, as well as the analysis of real data, confirm the good properties of the extended mBIC.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Model selection criterion, Multiple QTL, QTL interaction
in
Biometrics
volume
64
issue
4
pages
8 pages
publisher
INTERNATIONAL BIOMETRIC SOC,
external identifiers
  • pmid:18266892
  • scopus:54949119817
ISSN
0006-341X
DOI
10.1111/j.1541-0420.2008.00989.x
language
English
LU publication?
no
id
f623a94c-ac53-497f-ae07-cc633ae3ee19
date added to LUP
2023-12-08 09:23:55
date last changed
2024-02-04 19:19:30
@article{f623a94c-ac53-497f-ae07-cc633ae3ee19,
  abstract     = {{<p>The modified version of Bayesian Information Criterion (mBIC) is a relatively simple model selection procedure that can be used when locating multiple interacting quantitative trait loci (QTL). Our earlier work demonstrated the statistical properties of mBIC for situations where the average genetic map interval is at least 5 cM. In this work mBIC is adapted to genome searches based on a dense map and, more importantly, to the situation where consecutive QTL and interactions are located by multiple interval mapping. Easy to use formulas for the extended mBIC are given. A simulation study, as well as the analysis of real data, confirm the good properties of the extended mBIC.</p>}},
  author       = {{Bogdan, Malgorzata and Frommlet, Florian and Biecek, Przemysław and Cheng, Riyan and Ghosh, Jayanta K. and Doerge, R. W.}},
  issn         = {{0006-341X}},
  keywords     = {{Model selection criterion; Multiple QTL; QTL interaction}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1162--1169}},
  publisher    = {{INTERNATIONAL BIOMETRIC SOC,}},
  series       = {{Biometrics}},
  title        = {{Extending the modified Bayesian Information Criterion (mBIC) to dense markers and multiple interval mapping}},
  url          = {{http://dx.doi.org/10.1111/j.1541-0420.2008.00989.x}},
  doi          = {{10.1111/j.1541-0420.2008.00989.x}},
  volume       = {{64}},
  year         = {{2008}},
}