Time to pregnancy among partners of men exposed to di(2-ethylhexyl)phthalate
(2002) In Scandinavian Journal of Work, Environment and Health 28(6). p.418-428- Abstract
- Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/ml(3).... (More)
- Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/ml(3). The fathers of only four pregnancies had DEHP exposure of >0.5 mg/m(3) during the time to pregnancy. The pregnancies of employed women with unexposed partners or pregnancies of employed men unexposed during the time to pregnancy formed the reference group. Results The fecundability ratio for time to pregnancy was 1.07 [95% confidence interval (95% Cl) 0.84-1.351 for those with low exposure and 0.97 (95% CI 0.70-1.33) for the highly exposed after adjustment for the father's age, mother's age, and length of recall. When the analyses were restricted to first pregnancy, the fecundability ratio was 1.13 (95% Cl 0.83-1.56) for low exposure and 1.02 (95% Cl 0.66-1.59) for high exposure. Conclusions Time to pregnancy is not prolonged among couples with paternal exposure to DEHP at a mean exposure level of <0.5 mg/ml. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/320072
- author
- Modigh, C M ; Bodin, S L V ; Lillienberg, L ; Dahlman-Hoglund, A ; Åkesson, Bengt LU and Axelsson, G
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- plasticizer, occupational exposure, fecundity, males, reproduction
- in
- Scandinavian Journal of Work, Environment and Health
- volume
- 28
- issue
- 6
- pages
- 418 - 428
- publisher
- Finnish Institute of Occupational Health
- external identifiers
-
- pmid:12539802
- wos:000180289400007
- scopus:0036961380
- ISSN
- 0355-3140
- language
- English
- LU publication?
- yes
- id
- f62d694a-3876-44e6-baa4-593c55a9ba0a (old id 320072)
- alternative location
- http://www.sjweh.fi/show_abstract.php?abstract_id=694
- date added to LUP
- 2016-04-01 12:22:45
- date last changed
- 2022-01-27 02:54:18
@article{f62d694a-3876-44e6-baa4-593c55a9ba0a, abstract = {{Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/ml(3). The fathers of only four pregnancies had DEHP exposure of >0.5 mg/m(3) during the time to pregnancy. The pregnancies of employed women with unexposed partners or pregnancies of employed men unexposed during the time to pregnancy formed the reference group. Results The fecundability ratio for time to pregnancy was 1.07 [95% confidence interval (95% Cl) 0.84-1.351 for those with low exposure and 0.97 (95% CI 0.70-1.33) for the highly exposed after adjustment for the father's age, mother's age, and length of recall. When the analyses were restricted to first pregnancy, the fecundability ratio was 1.13 (95% Cl 0.83-1.56) for low exposure and 1.02 (95% Cl 0.66-1.59) for high exposure. Conclusions Time to pregnancy is not prolonged among couples with paternal exposure to DEHP at a mean exposure level of <0.5 mg/ml.}}, author = {{Modigh, C M and Bodin, S L V and Lillienberg, L and Dahlman-Hoglund, A and Åkesson, Bengt and Axelsson, G}}, issn = {{0355-3140}}, keywords = {{plasticizer; occupational exposure; fecundity; males; reproduction}}, language = {{eng}}, number = {{6}}, pages = {{418--428}}, publisher = {{Finnish Institute of Occupational Health}}, series = {{Scandinavian Journal of Work, Environment and Health}}, title = {{Time to pregnancy among partners of men exposed to di(2-ethylhexyl)phthalate}}, url = {{http://www.sjweh.fi/show_abstract.php?abstract_id=694}}, volume = {{28}}, year = {{2002}}, }