Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization

Nordenbaek, C ; Johansen, J S ; Junker, P ; Borregaard, N ; Sørensen, O LU and Price, P A (1999) In The Journal of infectious diseases 180(5). p.6-1722
Abstract

The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum... (More)

The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum values were observed on day 1 and thereafter declined steeply to almost normal by day 3. During the first 10 days, there was a close relation between serum YKL-40 and markers of specific granules of neutrophils (serum lactoferrin and neutrophil gelatinase-associated lipocalin), which suggests that serum YKL-40 reflects exocytosis of specific granules of neutrophils in persons with acute bacterial pneumonia.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipokines, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/therapeutic use, Chitinase-3-Like Protein 1, Community-Acquired Infections/blood, Female, Glycoproteins/analysis, Hospitalization, Humans, Lectins, Male, Middle Aged, Neutrophils/immunology, Pneumonia, Bacterial/blood, Prospective Studies, Time Factors
in
The Journal of infectious diseases
volume
180
issue
5
pages
5 pages
publisher
Oxford University Press
external identifiers
  • pmid:10515841
  • scopus:0032704645
ISSN
0022-1899
DOI
10.1086/315050
language
English
LU publication?
no
id
f65e551c-ffc5-407a-833c-45fcd4139f9b
date added to LUP
2020-11-05 13:50:34
date last changed
2024-05-29 23:36:25
@article{f65e551c-ffc5-407a-833c-45fcd4139f9b,
  abstract     = {{<p>The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P&lt;.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P&lt;.05). Peak YKL-40 serum values were observed on day 1 and thereafter declined steeply to almost normal by day 3. During the first 10 days, there was a close relation between serum YKL-40 and markers of specific granules of neutrophils (serum lactoferrin and neutrophil gelatinase-associated lipocalin), which suggests that serum YKL-40 reflects exocytosis of specific granules of neutrophils in persons with acute bacterial pneumonia.</p>}},
  author       = {{Nordenbaek, C and Johansen, J S and Junker, P and Borregaard, N and Sørensen, O and Price, P A}},
  issn         = {{0022-1899}},
  keywords     = {{Adipokines; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Chitinase-3-Like Protein 1; Community-Acquired Infections/blood; Female; Glycoproteins/analysis; Hospitalization; Humans; Lectins; Male; Middle Aged; Neutrophils/immunology; Pneumonia, Bacterial/blood; Prospective Studies; Time Factors}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{6--1722}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of infectious diseases}},
  title        = {{YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization}},
  url          = {{http://dx.doi.org/10.1086/315050}},
  doi          = {{10.1086/315050}},
  volume       = {{180}},
  year         = {{1999}},
}