YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization
(1999) In The Journal of infectious diseases 180(5). p.6-1722- Abstract
The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum... (More)
The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum values were observed on day 1 and thereafter declined steeply to almost normal by day 3. During the first 10 days, there was a close relation between serum YKL-40 and markers of specific granules of neutrophils (serum lactoferrin and neutrophil gelatinase-associated lipocalin), which suggests that serum YKL-40 reflects exocytosis of specific granules of neutrophils in persons with acute bacterial pneumonia.
(Less)
- author
- Nordenbaek, C ; Johansen, J S ; Junker, P ; Borregaard, N ; Sørensen, O LU and Price, P A
- publishing date
- 1999-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adipokines, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/therapeutic use, Chitinase-3-Like Protein 1, Community-Acquired Infections/blood, Female, Glycoproteins/analysis, Hospitalization, Humans, Lectins, Male, Middle Aged, Neutrophils/immunology, Pneumonia, Bacterial/blood, Prospective Studies, Time Factors
- in
- The Journal of infectious diseases
- volume
- 180
- issue
- 5
- pages
- 5 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:0032704645
- pmid:10515841
- ISSN
- 0022-1899
- DOI
- 10.1086/315050
- language
- English
- LU publication?
- no
- id
- f65e551c-ffc5-407a-833c-45fcd4139f9b
- date added to LUP
- 2020-11-05 13:50:34
- date last changed
- 2024-08-22 07:23:20
@article{f65e551c-ffc5-407a-833c-45fcd4139f9b, abstract = {{<p>The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum values were observed on day 1 and thereafter declined steeply to almost normal by day 3. During the first 10 days, there was a close relation between serum YKL-40 and markers of specific granules of neutrophils (serum lactoferrin and neutrophil gelatinase-associated lipocalin), which suggests that serum YKL-40 reflects exocytosis of specific granules of neutrophils in persons with acute bacterial pneumonia.</p>}}, author = {{Nordenbaek, C and Johansen, J S and Junker, P and Borregaard, N and Sørensen, O and Price, P A}}, issn = {{0022-1899}}, keywords = {{Adipokines; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Chitinase-3-Like Protein 1; Community-Acquired Infections/blood; Female; Glycoproteins/analysis; Hospitalization; Humans; Lectins; Male; Middle Aged; Neutrophils/immunology; Pneumonia, Bacterial/blood; Prospective Studies; Time Factors}}, language = {{eng}}, number = {{5}}, pages = {{6--1722}}, publisher = {{Oxford University Press}}, series = {{The Journal of infectious diseases}}, title = {{YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization}}, url = {{http://dx.doi.org/10.1086/315050}}, doi = {{10.1086/315050}}, volume = {{180}}, year = {{1999}}, }