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Changes in the Tyrosine Phosphorylation of Mitogen‐Activated Protein Kinase in the Rat Hippocampus During and Following Severe Hypoglycemia

Kurihara, Junichi ; Hu, Bing‐Ren ‐R and Wieloch, Tadeusz LU (1994) In Journal of Neurochemistry 63(6). p.2346-2348
Abstract

Abstract: The changes in the levels of tyrosine‐phosphorylated proteins in the cytosolic fraction of the rat hippocampus subjected to severe hypoglycemia were analyzed. A marked increase in tyrosine phosphorylation of a 43‐kDa protein was observed at 30 min of isoelectric EEG and 30 min and 1 h of recovery. Immunostaining of the same blot with antibody against mitogen‐activated protein (MAP) kinase demonstrated a double band of ∼42 and 43 kDa. The increased tyrosine phosphorylation of MAP kinase during hypoglycemic coma and the early recovery period suggests that MAP kinase may be involved in neuronal degeneration and repair.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell death, Glutamate, Hypoglycemia, Mitogen‐activated protein kinase, Trophic factor, Tyrosine phosphorylation
in
Journal of Neurochemistry
volume
63
issue
6
pages
3 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:7525877
  • scopus:0028033159
ISSN
0022-3042
DOI
10.1046/j.1471-4159.1994.63062346.x
language
English
LU publication?
yes
id
f6a1de66-291b-48c3-ab3e-ef55cec8f1de
date added to LUP
2019-06-13 16:18:20
date last changed
2024-01-01 10:16:52
@misc{f6a1de66-291b-48c3-ab3e-ef55cec8f1de,
  abstract     = {{<p>Abstract: The changes in the levels of tyrosine‐phosphorylated proteins in the cytosolic fraction of the rat hippocampus subjected to severe hypoglycemia were analyzed. A marked increase in tyrosine phosphorylation of a 43‐kDa protein was observed at 30 min of isoelectric EEG and 30 min and 1 h of recovery. Immunostaining of the same blot with antibody against mitogen‐activated protein (MAP) kinase demonstrated a double band of ∼42 and 43 kDa. The increased tyrosine phosphorylation of MAP kinase during hypoglycemic coma and the early recovery period suggests that MAP kinase may be involved in neuronal degeneration and repair.</p>}},
  author       = {{Kurihara, Junichi and Hu, Bing‐Ren ‐R and Wieloch, Tadeusz}},
  issn         = {{0022-3042}},
  keywords     = {{Cell death; Glutamate; Hypoglycemia; Mitogen‐activated protein kinase; Trophic factor; Tyrosine phosphorylation}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{6}},
  pages        = {{2346--2348}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Neurochemistry}},
  title        = {{Changes in the Tyrosine Phosphorylation of Mitogen‐Activated Protein Kinase in the Rat Hippocampus During and Following Severe Hypoglycemia}},
  url          = {{http://dx.doi.org/10.1046/j.1471-4159.1994.63062346.x}},
  doi          = {{10.1046/j.1471-4159.1994.63062346.x}},
  volume       = {{63}},
  year         = {{1994}},
}