Changes in the Tyrosine Phosphorylation of Mitogen‐Activated Protein Kinase in the Rat Hippocampus During and Following Severe Hypoglycemia
(1994) In Journal of Neurochemistry 63(6). p.2346-2348- Abstract
Abstract: The changes in the levels of tyrosine‐phosphorylated proteins in the cytosolic fraction of the rat hippocampus subjected to severe hypoglycemia were analyzed. A marked increase in tyrosine phosphorylation of a 43‐kDa protein was observed at 30 min of isoelectric EEG and 30 min and 1 h of recovery. Immunostaining of the same blot with antibody against mitogen‐activated protein (MAP) kinase demonstrated a double band of ∼42 and 43 kDa. The increased tyrosine phosphorylation of MAP kinase during hypoglycemic coma and the early recovery period suggests that MAP kinase may be involved in neuronal degeneration and repair.
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https://lup.lub.lu.se/record/f6a1de66-291b-48c3-ab3e-ef55cec8f1de
- author
- Kurihara, Junichi ; Hu, Bing‐Ren ‐R and Wieloch, Tadeusz LU
- organization
- publishing date
- 1994-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cell death, Glutamate, Hypoglycemia, Mitogen‐activated protein kinase, Trophic factor, Tyrosine phosphorylation
- in
- Journal of Neurochemistry
- volume
- 63
- issue
- 6
- pages
- 3 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:7525877
- scopus:0028033159
- ISSN
- 0022-3042
- DOI
- 10.1046/j.1471-4159.1994.63062346.x
- language
- English
- LU publication?
- yes
- id
- f6a1de66-291b-48c3-ab3e-ef55cec8f1de
- date added to LUP
- 2019-06-13 16:18:20
- date last changed
- 2024-01-01 10:16:52
@misc{f6a1de66-291b-48c3-ab3e-ef55cec8f1de, abstract = {{<p>Abstract: The changes in the levels of tyrosine‐phosphorylated proteins in the cytosolic fraction of the rat hippocampus subjected to severe hypoglycemia were analyzed. A marked increase in tyrosine phosphorylation of a 43‐kDa protein was observed at 30 min of isoelectric EEG and 30 min and 1 h of recovery. Immunostaining of the same blot with antibody against mitogen‐activated protein (MAP) kinase demonstrated a double band of ∼42 and 43 kDa. The increased tyrosine phosphorylation of MAP kinase during hypoglycemic coma and the early recovery period suggests that MAP kinase may be involved in neuronal degeneration and repair.</p>}}, author = {{Kurihara, Junichi and Hu, Bing‐Ren ‐R and Wieloch, Tadeusz}}, issn = {{0022-3042}}, keywords = {{Cell death; Glutamate; Hypoglycemia; Mitogen‐activated protein kinase; Trophic factor; Tyrosine phosphorylation}}, language = {{eng}}, month = {{01}}, number = {{6}}, pages = {{2346--2348}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Neurochemistry}}, title = {{Changes in the Tyrosine Phosphorylation of Mitogen‐Activated Protein Kinase in the Rat Hippocampus During and Following Severe Hypoglycemia}}, url = {{http://dx.doi.org/10.1046/j.1471-4159.1994.63062346.x}}, doi = {{10.1046/j.1471-4159.1994.63062346.x}}, volume = {{63}}, year = {{1994}}, }