Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation : Lights Up Therapeutic Intervention for Neurodegeneration

Yuan, Lin ; Mao, Li Hong and Li, Jia Yi LU (2025) In Aging and Disease 16(1). p.1-4
Abstract

N1-methyladenine (m1A), a modification of transcripts, regulates mRNA structure and translation efficiency. In a recent issue of Nature, Sun et al. reported that m1A in CAG repeat RNA contributes to CAG repeat expansion-induced neurodegeneration in Caenorhabditis elegans and Drosophila through enhancing the ability of endogenous TDP-43 to partition into stress granules mediated by m1A. The study is especially important for revealing the pathological function of m1A in RNA and the pathological mechanisms of CAG repeat expansion-related neurodegenerative diseases.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CAG repeat expansion, gel-like aggregates, mA, TDP-43
in
Aging and Disease
volume
16
issue
1
pages
4 pages
publisher
Buck Institute for Age Research
external identifiers
  • scopus:85204018625
  • pmid:38502588
ISSN
2152-5250
DOI
10.14336/AD.2024.0110
language
English
LU publication?
yes
id
f6d20ff8-9222-4682-9a80-bea5d93c5a7b
date added to LUP
2026-01-09 14:39:22
date last changed
2026-01-10 03:00:08
@article{f6d20ff8-9222-4682-9a80-bea5d93c5a7b,
  abstract     = {{<p>N<sup>1</sup>-methyladenine (m<sup>1</sup>A), a modification of transcripts, regulates mRNA structure and translation efficiency. In a recent issue of Nature, Sun et al. reported that m<sup>1</sup>A in CAG repeat RNA contributes to CAG repeat expansion-induced neurodegeneration in Caenorhabditis elegans and Drosophila through enhancing the ability of endogenous TDP-43 to partition into stress granules mediated by m<sup>1</sup>A. The study is especially important for revealing the pathological function of m<sup>1</sup>A in RNA and the pathological mechanisms of CAG repeat expansion-related neurodegenerative diseases.</p>}},
  author       = {{Yuan, Lin and Mao, Li Hong and Li, Jia Yi}},
  issn         = {{2152-5250}},
  keywords     = {{CAG repeat expansion; gel-like aggregates; mA; TDP-43}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--4}},
  publisher    = {{Buck Institute for Age Research}},
  series       = {{Aging and Disease}},
  title        = {{CAG Repeat Expansions Increase N<sup>1</sup>-Methyladenine to Alter TDP-43 Phase Separation : Lights Up Therapeutic Intervention for Neurodegeneration}},
  url          = {{http://dx.doi.org/10.14336/AD.2024.0110}},
  doi          = {{10.14336/AD.2024.0110}},
  volume       = {{16}},
  year         = {{2025}},
}