Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans
Lu, Zhiya ; Zhang, Haoyang LU
; Yang, Yuanhao
and Zhao, Huiying
(2023)
In Human Genetics
142(7).
p.965-980
- Abstract
Type 2 diabetes (T2D) is a critical risk factor for peripheral artery disease (PAD). However, the sex differences in genetic basis, causality, and underlying mechanisms of the two diseases are still unclear. Using sex-stratified and ethnic-based GWAS summary, we explored the genetic correlation and causal relationship between T2D and PAD in both ethnicities and sexes by linkage disequilibrium score regression, LAVA and six Mendelian Randomization approaches. We observed stronger genetic correlations between T2D and PAD in females than males in East Asians and Europeans. East Asian females exhibit higher causal effects of T2D on PAD than males. The gene-level analysis found KCNJ11 and ANK1 genes associated with the cross-trait of T2D and... (More)
Type 2 diabetes (T2D) is a critical risk factor for peripheral artery disease (PAD). However, the sex differences in genetic basis, causality, and underlying mechanisms of the two diseases are still unclear. Using sex-stratified and ethnic-based GWAS summary, we explored the genetic correlation and causal relationship between T2D and PAD in both ethnicities and sexes by linkage disequilibrium score regression, LAVA and six Mendelian Randomization approaches. We observed stronger genetic correlations between T2D and PAD in females than males in East Asians and Europeans. East Asian females exhibit higher causal effects of T2D on PAD than males. The gene-level analysis found KCNJ11 and ANK1 genes associated with the cross-trait of T2D and PAD in both sexes. Our study provides genetic evidence for the sex difference of genetic correlations and causal relationships between PAD and T2D, indicating the importance of using sex-specific strategies for monitoring PAD in T2D patients.
(Less)
- author
- Lu, Zhiya
; Zhang, Haoyang
LU
; Yang, Yuanhao
and Zhao, Huiying
- publishing date
- 2023-07
- type
- Contribution to journal
- publication status
- published
- keywords
- Female, Humans, Male, Diabetes Mellitus, Type 2/genetics, East Asian People, European People, Genome-Wide Association Study, Mendelian Randomization Analysis, Peripheral Arterial Disease/genetics, Polymorphism, Single Nucleotide, Sex Factors
- in
- Human Genetics
- volume
- 142
- issue
- 7
- pages
- 965 - 980
- publisher
- Springer
- external identifiers
-
- scopus:85162246957
- pmid:37341850
- ISSN
- 1432-1203
- DOI
- 10.1007/s00439-023-02573-x
- language
- English
- LU publication?
- no
- additional info
- © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- id
- f6dc3e1e-6a2e-453b-836d-9f8da4b448cd
- date added to LUP
- 2024-02-05 15:04:20
- date last changed
- 2024-04-22 10:54:57
@article{f6dc3e1e-6a2e-453b-836d-9f8da4b448cd,
abstract = {{<p>Type 2 diabetes (T2D) is a critical risk factor for peripheral artery disease (PAD). However, the sex differences in genetic basis, causality, and underlying mechanisms of the two diseases are still unclear. Using sex-stratified and ethnic-based GWAS summary, we explored the genetic correlation and causal relationship between T2D and PAD in both ethnicities and sexes by linkage disequilibrium score regression, LAVA and six Mendelian Randomization approaches. We observed stronger genetic correlations between T2D and PAD in females than males in East Asians and Europeans. East Asian females exhibit higher causal effects of T2D on PAD than males. The gene-level analysis found KCNJ11 and ANK1 genes associated with the cross-trait of T2D and PAD in both sexes. Our study provides genetic evidence for the sex difference of genetic correlations and causal relationships between PAD and T2D, indicating the importance of using sex-specific strategies for monitoring PAD in T2D patients.</p>}},
author = {{Lu, Zhiya and Zhang, Haoyang and Yang, Yuanhao and Zhao, Huiying}},
issn = {{1432-1203}},
keywords = {{Female; Humans; Male; Diabetes Mellitus, Type 2/genetics; East Asian People; European People; Genome-Wide Association Study; Mendelian Randomization Analysis; Peripheral Arterial Disease/genetics; Polymorphism, Single Nucleotide; Sex Factors}},
language = {{eng}},
number = {{7}},
pages = {{965--980}},
publisher = {{Springer}},
series = {{Human Genetics}},
title = {{Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans}},
url = {{http://dx.doi.org/10.1007/s00439-023-02573-x}},
doi = {{10.1007/s00439-023-02573-x}},
volume = {{142}},
year = {{2023}},
}