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P-Coumaric Acid Mitigates Doxorubicin-Induced Nephrotoxicity Through Suppression of Oxidative Stress, Inflammation and Apoptosis

Rafiee, Zeinab LU ; Moaiedi, Maasoumeh Zare ; Gorji, Armita Valizade and Mansouri, Esrafil (2020) In Archives of Medical Research 51(1). p.32-40
Abstract
Background and Aims
P-Coumaric acid (PCA) is one the compound that has free radical scavenging effects. This study investigates the protective effect of PCA on tissue damage in DOX-induced nephrotoxicity.

Methods
Thirty two Wistar rats were divided into control, PCA, DOX (15 mg/kg, i.p.) and DOX plus PCA (100 mg/kg, orally) groups. DOX-induced nephrotoxicity was indicated by marked increase in blood urea nitrogen (BUN) and serum creatinine (Cr) compared to controls. DOX group also showed elevations in lipid peroxidation and reductions in enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). Expression of renal inflammatory cytokines including tumor necrosis factor alpha (TNF-α)... (More)
Background and Aims
P-Coumaric acid (PCA) is one the compound that has free radical scavenging effects. This study investigates the protective effect of PCA on tissue damage in DOX-induced nephrotoxicity.

Methods
Thirty two Wistar rats were divided into control, PCA, DOX (15 mg/kg, i.p.) and DOX plus PCA (100 mg/kg, orally) groups. DOX-induced nephrotoxicity was indicated by marked increase in blood urea nitrogen (BUN) and serum creatinine (Cr) compared to controls. DOX group also showed elevations in lipid peroxidation and reductions in enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). Expression of renal inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) and apoptosis were also elevated in the DOX group.

Results
PCA significantly reversed, nephrotoxicity induced by DOX via lowering BUN, serum Cr and improving histopathological scores as compared to the DOX group. PCA also decreased lipid peroxidation, increased activities of GPx, SOD and CAT, to levels relatively comparable to control. Significant reductions in expression of TNF-α, IL-1β and apoptosis were also observed following Co-administration of PCA relative to the DOX group.

Conclusions
Results describe a protective effect of PCA against DOX-induced nephrotoxicity. This effect is likely facilitated through inhibition of oxidative stress, inflammation and apoptosis. (Less)
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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Doxorubicin, Nephrotoxicity, p-Coumaric acid, Oxidative stress, inflammatory markers, Apoptosis
in
Archives of Medical Research
volume
51
issue
1
pages
32 - 40
publisher
Elsevier
external identifiers
  • pmid:32086107
  • scopus:85079402919
ISSN
0188-4409
DOI
10.1016/j.arcmed.2019.12.004
language
English
LU publication?
no
id
f6ecddbc-2714-4cd8-84e6-d2ea4105cade
date added to LUP
2021-09-23 20:29:44
date last changed
2022-04-27 04:10:17
@article{f6ecddbc-2714-4cd8-84e6-d2ea4105cade,
  abstract     = {{Background and Aims<br/>P-Coumaric acid (PCA) is one the compound that has free radical scavenging effects. This study investigates the protective effect of PCA on tissue damage in DOX-induced nephrotoxicity.<br/><br/>Methods<br/>Thirty two Wistar rats were divided into control, PCA, DOX (15 mg/kg, i.p.) and DOX plus PCA (100 mg/kg, orally) groups. DOX-induced nephrotoxicity was indicated by marked increase in blood urea nitrogen (BUN) and serum creatinine (Cr) compared to controls. DOX group also showed elevations in lipid peroxidation and reductions in enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). Expression of renal inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) and apoptosis were also elevated in the DOX group.<br/><br/>Results<br/>PCA significantly reversed, nephrotoxicity induced by DOX via lowering BUN, serum Cr and improving histopathological scores as compared to the DOX group. PCA also decreased lipid peroxidation, increased activities of GPx, SOD and CAT, to levels relatively comparable to control. Significant reductions in expression of TNF-α, IL-1β and apoptosis were also observed following Co-administration of PCA relative to the DOX group.<br/><br/>Conclusions<br/>Results describe a protective effect of PCA against DOX-induced nephrotoxicity. This effect is likely facilitated through inhibition of oxidative stress, inflammation and apoptosis.}},
  author       = {{Rafiee, Zeinab and Moaiedi, Maasoumeh Zare and Gorji, Armita Valizade and Mansouri, Esrafil}},
  issn         = {{0188-4409}},
  keywords     = {{Doxorubicin; Nephrotoxicity; p-Coumaric acid; Oxidative stress; inflammatory markers; Apoptosis}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{32--40}},
  publisher    = {{Elsevier}},
  series       = {{Archives of Medical Research}},
  title        = {{P-Coumaric Acid Mitigates Doxorubicin-Induced Nephrotoxicity Through Suppression of Oxidative Stress, Inflammation and Apoptosis}},
  url          = {{http://dx.doi.org/10.1016/j.arcmed.2019.12.004}},
  doi          = {{10.1016/j.arcmed.2019.12.004}},
  volume       = {{51}},
  year         = {{2020}},
}