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Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

Dong, Catherine ; Chan, Simon S M ; Jantchou, Prevost ; Racine, Antoine ; Oldenburg, Bas ; Weiderpass, Elisabete ; Heath, Alicia K ; Tong, Tammy Y N ; Tjønneland, Anne and Kyrø, Cecilie , et al. (2022) In Journal of Crohn's & Colitis
Abstract

BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.

METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.

RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative... (More)

BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.

METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.

RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk.

CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.

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publishing date
type
Contribution to journal
publication status
epub
subject
in
Journal of Crohn's & Colitis
publisher
Oxford University Press
external identifiers
  • pmid:35396592
ISSN
1873-9946
DOI
10.1093/ecco-jcc/jjac054
language
English
LU publication?
no
additional info
© The Author(s) 2022. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.
id
f6edc9d6-8efa-4fec-8039-9e73534d45da
date added to LUP
2022-04-22 13:33:41
date last changed
2022-04-22 14:24:49
@article{f6edc9d6-8efa-4fec-8039-9e73534d45da,
  abstract     = {{<p>BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.</p><p>METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.</p><p>RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk.</p><p>CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.</p>}},
  author       = {{Dong, Catherine and Chan, Simon S M and Jantchou, Prevost and Racine, Antoine and Oldenburg, Bas and Weiderpass, Elisabete and Heath, Alicia K and Tong, Tammy Y N and Tjønneland, Anne and Kyrø, Cecilie and de Mesquita, Bas Bueno and Kaaks, Rudolf and Katzke, Verena A and Bergman, Manuela M and Boeing, Heiner and Palli, Domenico and Masala, Giovanna and Tumino, Rosario and Sacerdote, Carlotta and Colorado-Yohar, Sandra M and Sánchez, Maria-Jose and Grip, Olof and Lindgren, Stefan and Luben, Robert and Huybrechts, Inge and Gunter, Marc J and Mahamat-Saleh, Yahya and Boutron-Ruault, Marie-Christine and Carbonnel, Franck}},
  issn         = {{1873-9946}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Crohn's & Colitis}},
  title        = {{Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study}},
  url          = {{http://dx.doi.org/10.1093/ecco-jcc/jjac054}},
  doi          = {{10.1093/ecco-jcc/jjac054}},
  year         = {{2022}},
}