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Bacillus subtilis contains two small c-type cytochromes with homologous heme-domains but different types of membrane-anchors

Bengtsson, Jenny LU ; Rivolta, Carlo; Hederstedt, Lars LU and Karamata, Dimitri (1999) In Journal of Biological Chemistry 274. p.26179-26184
Abstract
We demonstrate that the cccB gene, identified in the Bacillus subtilis genome sequence project, is the structural gene for a 10-kDa membrane-bound cytochrome c551 lipoprotein described for the first time in B. subtilis. Apparently, CccB corresponds to cytochrome c551 of the thermophilic bacterium Bacillus PS3. The heme domain of B. subtilis cytochrome c551 is very similar to that of cytochrome c550, a protein encoded by the cccA gene and anchored to the membrane by a single transmembrane polypeptide segment. Thus, B. subtilis contains two small, very similar, c-type cytochromes with different types of membrane anchors. The cccB gene is cotranscribed with the yvjA gene, and transcription is repressed by glucose. Mutants deleted for cccB or... (More)
We demonstrate that the cccB gene, identified in the Bacillus subtilis genome sequence project, is the structural gene for a 10-kDa membrane-bound cytochrome c551 lipoprotein described for the first time in B. subtilis. Apparently, CccB corresponds to cytochrome c551 of the thermophilic bacterium Bacillus PS3. The heme domain of B. subtilis cytochrome c551 is very similar to that of cytochrome c550, a protein encoded by the cccA gene and anchored to the membrane by a single transmembrane polypeptide segment. Thus, B. subtilis contains two small, very similar, c-type cytochromes with different types of membrane anchors. The cccB gene is cotranscribed with the yvjA gene, and transcription is repressed by glucose. Mutants deleted for cccB or yvjA-cccB show no apparent growth, sporulation, or germination defect. YvjA is not required for the synthesis of cytochrome c551, and its function remains unknown. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Biological Chemistry
volume
274
pages
26179 - 26184
publisher
ASBMB
ISSN
1083-351X
DOI
10.1074/jbc.274.37.26179
language
English
LU publication?
yes
id
f756333f-812a-46f0-8774-6a3ba65fa480
date added to LUP
2017-07-18 09:43:58
date last changed
2017-08-11 11:35:54
@article{f756333f-812a-46f0-8774-6a3ba65fa480,
  abstract     = {We demonstrate that the cccB gene, identified in the Bacillus subtilis genome sequence project, is the structural gene for a 10-kDa membrane-bound cytochrome c551 lipoprotein described for the first time in B. subtilis. Apparently, CccB corresponds to cytochrome c551 of the thermophilic bacterium Bacillus PS3. The heme domain of B. subtilis cytochrome c551 is very similar to that of cytochrome c550, a protein encoded by the cccA gene and anchored to the membrane by a single transmembrane polypeptide segment. Thus, B. subtilis contains two small, very similar, c-type cytochromes with different types of membrane anchors. The cccB gene is cotranscribed with the yvjA gene, and transcription is repressed by glucose. Mutants deleted for cccB or yvjA-cccB show no apparent growth, sporulation, or germination defect. YvjA is not required for the synthesis of cytochrome c551, and its function remains unknown.},
  author       = {Bengtsson, Jenny and Rivolta, Carlo and Hederstedt, Lars and Karamata, Dimitri},
  issn         = {1083-351X},
  language     = {eng},
  pages        = {26179--26184},
  publisher    = {ASBMB},
  series       = {Journal of Biological Chemistry},
  title        = {<em>Bacillus subtilis</em> contains two small c-type cytochromes with homologous heme-domains but different types of membrane-anchors},
  url          = {http://dx.doi.org/10.1074/jbc.274.37.26179  },
  volume       = {274},
  year         = {1999},
}