Effects of protein malnutrition on tolerance to helminth infection
(2016) In Biology letters 12(6).- Abstract
Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that... (More)
Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that is, there was a host genotype-by-environment interaction for tolerance. We conclude that nutritional status can affect tolerance and that sensitivity of tolerance to malnutrition may differ between host genotypes.
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- author
- Clough, Dagmar LU ; Prykhodko, Olena LU and Råberg, Lars LU
- organization
- publishing date
- 2016-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- helminth, intestinal permeability, resistance, tolerance
- in
- Biology letters
- volume
- 12
- issue
- 6
- article number
- 20160189
- pages
- 4 pages
- publisher
- Royal Society Publishing
- external identifiers
-
- pmid:27330171
- scopus:85010069156
- wos:000386717900014
- ISSN
- 1744-9561
- DOI
- 10.1098/rsbl.2016.0189
- language
- English
- LU publication?
- yes
- id
- f75aae6b-3ef3-44e8-ab83-d33e5813f3a6
- date added to LUP
- 2016-11-08 11:30:32
- date last changed
- 2024-05-17 15:39:51
@article{f75aae6b-3ef3-44e8-ab83-d33e5813f3a6,
abstract = {{<p>Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that is, there was a host genotype-by-environment interaction for tolerance. We conclude that nutritional status can affect tolerance and that sensitivity of tolerance to malnutrition may differ between host genotypes.</p>}},
author = {{Clough, Dagmar and Prykhodko, Olena and Råberg, Lars}},
issn = {{1744-9561}},
keywords = {{helminth; intestinal permeability; resistance; tolerance}},
language = {{eng}},
number = {{6}},
publisher = {{Royal Society Publishing}},
series = {{Biology letters}},
title = {{Effects of protein malnutrition on tolerance to helminth infection}},
url = {{http://dx.doi.org/10.1098/rsbl.2016.0189}},
doi = {{10.1098/rsbl.2016.0189}},
volume = {{12}},
year = {{2016}},
}