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Effects of protein malnutrition on tolerance to helminth infection

Clough, Dagmar LU ; Prykhodko, Olena LU and Råberg, Lars LU (2016) In Biology Letters 12(6).
Abstract

Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that... (More)

Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that is, there was a host genotype-by-environment interaction for tolerance. We conclude that nutritional status can affect tolerance and that sensitivity of tolerance to malnutrition may differ between host genotypes.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
helminth, intestinal permeability, resistance, tolerance
in
Biology Letters
volume
12
issue
6
pages
4 pages
publisher
Royal Society
external identifiers
  • scopus:85010069156
  • wos:000386717900014
ISSN
1744-9561
DOI
10.1098/rsbl.2016.0189
language
English
LU publication?
yes
id
f75aae6b-3ef3-44e8-ab83-d33e5813f3a6
date added to LUP
2016-11-08 11:30:32
date last changed
2017-09-18 11:29:36
@article{f75aae6b-3ef3-44e8-ab83-d33e5813f3a6,
  abstract     = {<p>Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that is, there was a host genotype-by-environment interaction for tolerance. We conclude that nutritional status can affect tolerance and that sensitivity of tolerance to malnutrition may differ between host genotypes.</p>},
  articleno    = {20160189},
  author       = {Clough, Dagmar and Prykhodko, Olena and Råberg, Lars},
  issn         = {1744-9561},
  keyword      = {helminth,intestinal permeability,resistance,tolerance},
  language     = {eng},
  number       = {6},
  pages        = {4},
  publisher    = {Royal Society},
  series       = {Biology Letters},
  title        = {Effects of protein malnutrition on tolerance to helminth infection},
  url          = {http://dx.doi.org/10.1098/rsbl.2016.0189},
  volume       = {12},
  year         = {2016},
}