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CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.

Ericsson, Anna LU ; Svensson Frej, Marcus LU ; Arya, Anu and Agace, William LU (2004) In European Journal of Immunology 34(10). p.2720-2729
Abstract
The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site.... (More)
The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8+ IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T lymphocyte, Chemokine, Integrin, Adhesion, Epithelium
in
European Journal of Immunology
volume
34
issue
10
pages
2720 - 2729
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000224517800011
  • pmid:15368288
  • scopus:7244248660
ISSN
1521-4141
DOI
10.1002/eji.200425125
language
English
LU publication?
yes
id
f78779a7-4e6a-467a-8c42-e052e20aa940 (old id 127383)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15368288&dopt=Abstract
date added to LUP
2016-04-01 11:38:13
date last changed
2022-01-26 07:59:55
@article{f78779a7-4e6a-467a-8c42-e052e20aa940,
  abstract     = {{The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8+ IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa.}},
  author       = {{Ericsson, Anna and Svensson Frej, Marcus and Arya, Anu and Agace, William}},
  issn         = {{1521-4141}},
  keywords     = {{T lymphocyte; Chemokine; Integrin; Adhesion; Epithelium}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2720--2729}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{European Journal of Immunology}},
  title        = {{CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.}},
  url          = {{http://dx.doi.org/10.1002/eji.200425125}},
  doi          = {{10.1002/eji.200425125}},
  volume       = {{34}},
  year         = {{2004}},
}